Entry | Database: PDB / ID: 2mk2 |
---|
Title | Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A |
---|
Components | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
---|
Keywords | HYDROLASE / Structural Genomics / NORTHEAST STRUCTURAL GENOMICS CONSORTIUM / NESG / PSI-Biology / Protein Structure Initiative |
---|
Function / homology | Function and homology information
negative regulation of insulin-like growth factor receptor signaling pathway / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity / inositol-polyphosphate 5-phosphatase activity / ruffle assembly / regulation of actin filament organization / phosphatidylinositol dephosphorylation / endochondral ossification / phosphatidylinositol biosynthetic process / immune system process ...negative regulation of insulin-like growth factor receptor signaling pathway / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity / inositol-polyphosphate 5-phosphatase activity / ruffle assembly / regulation of actin filament organization / phosphatidylinositol dephosphorylation / endochondral ossification / phosphatidylinositol biosynthetic process / immune system process / Synthesis of IP3 and IP4 in the cytosol / establishment of mitotic spindle orientation / Synthesis of PIPs at the plasma membrane / regulation of immune response / Interleukin receptor SHC signaling / SH2 domain binding / basal plasma membrane / post-embryonic development / filopodium / actin filament organization / response to insulin / SH3 domain binding / spindle pole / endocytosis / glucose metabolic process / Signaling by CSF1 (M-CSF) in myeloid cells / regulation of protein localization / lamellipodium / actin binding / cell adhesion / nuclear speck / negative regulation of cell population proliferation / negative regulation of gene expression / Golgi apparatus / nucleus / cytosolSimilarity search - Function Inositol polyphosphate-related phosphatase / Inositol polyphosphate phosphatase, catalytic domain homologues / SAM domain (Sterile alpha motif) / Endonuclease/exonuclease/phosphatase superfamily / SH2 domain / SHC Adaptor Protein / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily ...Inositol polyphosphate-related phosphatase / Inositol polyphosphate phosphatase, catalytic domain homologues / SAM domain (Sterile alpha motif) / Endonuclease/exonuclease/phosphatase superfamily / SH2 domain / SHC Adaptor Protein / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) |
---|
Method | SOLUTION NMR / simulated annealing |
---|
Model details | lowest energy, model 1 |
---|
Authors | Yang, Y. / Ramelot, T.A. / Janjua, H. / Xiao, R. / Everett, J.K. / Montelione, G.T. / Kennedy, M.A. / Northeast Structural Genomics Consortium (NESG) |
---|
Citation | Journal: To be Published Title: Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A. Authors: Yang, Y. / Ramelot, T.A. / Janjua, H. / Xiao, R. / Everett, J.K. / Montelione, G.T. / Kennedy, M.A. |
---|
History | Deposition | Jan 23, 2014 | Deposition site: BMRB / Processing site: RCSB |
---|
Revision 1.0 | Mar 5, 2014 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jun 14, 2023 | Group: Data collection / Database references / Other Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
---|
|
---|