登録情報 | データベース: PDB / ID: 2mcz |
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タイトル | CR1 Sushi domains 1 and 2 |
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要素 | Complement receptor type 1 |
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キーワード | IMMUNE SYSTEM / CR1 / PfRh4 / malaria / CCP |
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機能・相同性 | 機能・相同性情報
complement component C4b receptor activity / immune complex clearance by erythrocytes / complement component C3b receptor activity / positive regulation of serine-type endopeptidase activity / negative regulation of complement activation, alternative pathway / complement component C4b binding / negative regulation of immunoglobulin production / negative regulation of activation of membrane attack complex / negative regulation of complement-dependent cytotoxicity / negative regulation of complement activation ...complement component C4b receptor activity / immune complex clearance by erythrocytes / complement component C3b receptor activity / positive regulation of serine-type endopeptidase activity / negative regulation of complement activation, alternative pathway / complement component C4b binding / negative regulation of immunoglobulin production / negative regulation of activation of membrane attack complex / negative regulation of complement-dependent cytotoxicity / negative regulation of complement activation / ATP export / positive regulation of activation of membrane attack complex / plasma membrane organization / negative regulation of complement activation, classical pathway / negative regulation of plasma cell differentiation / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / complement component C3b binding / T cell mediated immunity / negative regulation of serine-type endopeptidase activity / complement receptor mediated signaling pathway / positive regulation of regulatory T cell differentiation / complement activation, alternative pathway / negative regulation of interleukin-2 production / plasma membrane raft / ficolin-1-rich granule membrane / negative regulation of type II interferon production / negative regulation of T cell proliferation / secretory granule membrane / complement activation, classical pathway / Regulation of Complement cascade / virus receptor activity / cytoskeleton / positive regulation of cell population proliferation / Neutrophil degranulation / cell surface / extracellular space / extracellular exosome / plasma membrane類似検索 - 分子機能 Complement Module, domain 1 / Complement Module; domain 1 / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Ribbon / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Park, H.J. / Guariento, M.J. / Maciejewski, M. / Hauart, R. / Tham, W. / Cowman, A.F. / Schmidt, C.Q. / Martens, H. / Liszewski, K.M. / Hourcade, D. ...Park, H.J. / Guariento, M.J. / Maciejewski, M. / Hauart, R. / Tham, W. / Cowman, A.F. / Schmidt, C.Q. / Martens, H. / Liszewski, K.M. / Hourcade, D. / Barlow, P.N. / Atkinson, J.P. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2014 タイトル: Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor. 著者: Park, H.J. / Guariento, M. / Maciejewski, M. / Hauhart, R. / Tham, W.H. / Cowman, A.F. / Schmidt, C.Q. / Mertens, H.D. / Liszewski, M.K. / Hourcade, D.E. / Barlow, P.N. / Atkinson, J.P. |
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履歴 | 登録 | 2013年8月27日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2013年11月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年12月4日 | Group: Database references |
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改定 1.2 | 2014年1月22日 | Group: Database references |
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改定 1.3 | 2023年6月14日 | Group: Data collection / Database references / Other カテゴリ: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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Remark 700 | SHEET DETERMINATION METHOD: AUTHOR DETERMINED |
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