- PDB-2m5b: The NMR structure of the BID-BAK complex -
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Basic information
Entry
Database: PDB / ID: 2m5b
Title
The NMR structure of the BID-BAK complex
Components
Bcl-2 homologous antagonist/killer
human_BID_BH3_SAHB
Keywords
APOPTOSIS / BCL-2 family effector BAK / BH3-only protein BID / effector direct activation / NMR solution structure of BID-BAK complex / mitochondrial outer membrane premeabilization
Function / homology
Function and homology information
cysteine-type endopeptidase regulator activity involved in apoptotic process / mitochondrial outer membrane permeabilization / Activation, translocation and oligomerization of BAX / Activation and oligomerization of BAK protein / response to mycotoxin / Activation, myristolyation of BID and translocation to mitochondria / B cell negative selection / BAK complex / apoptotic process involved in blood vessel morphogenesis / response to fungus ...cysteine-type endopeptidase regulator activity involved in apoptotic process / mitochondrial outer membrane permeabilization / Activation, translocation and oligomerization of BAX / Activation and oligomerization of BAK protein / response to mycotoxin / Activation, myristolyation of BID and translocation to mitochondria / B cell negative selection / BAK complex / apoptotic process involved in blood vessel morphogenesis / response to fungus / negative regulation of endoplasmic reticulum calcium ion concentration / positive regulation of fibroblast apoptotic process / limb morphogenesis / Release of apoptotic factors from the mitochondria / endocrine pancreas development / post-embryonic camera-type eye morphogenesis / establishment or maintenance of transmembrane electrochemical gradient / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / B cell apoptotic process / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / protein targeting to mitochondrion / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / activation of cysteine-type endopeptidase activity / regulation of epithelial cell proliferation / establishment of protein localization to membrane / death receptor binding / positive regulation of endoplasmic reticulum unfolded protein response / endoplasmic reticulum calcium ion homeostasis / positive regulation of extrinsic apoptotic signaling pathway / regulation of mitochondrial membrane permeability / positive regulation of mitochondrial membrane potential / calcium ion transport into cytosol / BH domain binding / response to UV-C / fibroblast apoptotic process / mitochondrial fusion / Bcl-2 family protein complex / myeloid cell homeostasis / positive regulation of calcium ion transport into cytosol / porin activity / regulation of T cell proliferation / hepatocyte apoptotic process / thymocyte apoptotic process / pore complex / negative regulation of release of cytochrome c from mitochondria / negative regulation of peptidyl-serine phosphorylation / regulation of G1/S transition of mitotic cell cycle / positive regulation of IRE1-mediated unfolded protein response / positive regulation of release of cytochrome c from mitochondria / apoptotic mitochondrial changes / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / vagina development / mitochondrial ATP synthesis coupled electron transport / B cell homeostasis / positive regulation of proteolysis / extrinsic apoptotic signaling pathway via death domain receptors / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / Activation of BAD and translocation to mitochondria / blood vessel remodeling / signal transduction in response to DNA damage / cellular response to unfolded protein / Pyroptosis / animal organ regeneration / supramolecular fiber organization / positive regulation of intrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / heat shock protein binding / intrinsic apoptotic signaling pathway / release of cytochrome c from mitochondria / regulation of mitochondrial membrane potential / epithelial cell proliferation / establishment of localization in cell / response to gamma radiation / apoptotic signaling pathway / positive regulation of protein-containing complex assembly / response to hydrogen peroxide / response to organic cyclic compound / cellular response to mechanical stimulus / intrinsic apoptotic signaling pathway in response to DNA damage / cellular response to UV / protein-folding chaperone binding / protein-containing complex assembly / neuron apoptotic process / response to ethanol / transmembrane transporter binding / mitochondrial outer membrane / regulation of cell cycle / response to xenobiotic stimulus / positive regulation of apoptotic process / protein heterodimerization activity / negative regulation of cell population proliferation / negative regulation of gene expression / ubiquitin protein ligase binding / protein-containing complex binding / apoptotic process / endoplasmic reticulum / protein homodimerization activity / mitochondrion / identical protein binding Similarity search - Function
BH3-interacting domain death agonist / BH3 interacting domain (BID) / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. ...BH3-interacting domain death agonist / BH3 interacting domain (BID) / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
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