登録情報 | データベース: PDB / ID: 2m1w |
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タイトル | TICAM-2 TIR domain |
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要素 | TIR domain-containing adapter molecule 2 |
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キーワード | IMMUNE SYSTEM / TIR domain / TICAM-2 / TRAM / innate immunity / Interferon |
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機能・相同性 | 機能・相同性情報
MyD88-independent toll-like receptor signaling pathway / TRAM-dependent toll-like receptor 4 signaling pathway / positive regulation of interleukin-18-mediated signaling pathway / negative regulation of chemokine (C-C motif) ligand 5 production / negative regulation of MyD88-independent toll-like receptor signaling pathway / neutrophil degranulation / MyD88-independent TLR4 cascade / positive regulation of toll-like receptor 4 signaling pathway / TRIF-mediated programmed cell death / negative regulation of toll-like receptor 4 signaling pathway ...MyD88-independent toll-like receptor signaling pathway / TRAM-dependent toll-like receptor 4 signaling pathway / positive regulation of interleukin-18-mediated signaling pathway / negative regulation of chemokine (C-C motif) ligand 5 production / negative regulation of MyD88-independent toll-like receptor signaling pathway / neutrophil degranulation / MyD88-independent TLR4 cascade / positive regulation of toll-like receptor 4 signaling pathway / TRIF-mediated programmed cell death / negative regulation of toll-like receptor 4 signaling pathway / positive regulation of chemokine (C-C motif) ligand 5 production / Caspase activation via Death Receptors in the presence of ligand / Toll Like Receptor 4 (TLR4) Cascade / TRIF-dependent toll-like receptor signaling pathway / toll-like receptor 4 signaling pathway / COPII-coated ER to Golgi transport vesicle / Golgi organization / necroptotic process / phagocytic cup / endoplasmic reticulum-Golgi intermediate compartment / canonical NF-kappaB signal transduction / endoplasmic reticulum to Golgi vesicle-mediated transport / phagocytosis / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / TRAF6-mediated induction of TAK1 complex within TLR4 complex / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / IKK complex recruitment mediated by RIP1 / secretory granule membrane / cell projection / apoptotic signaling pathway / intracellular protein transport / late endosome / late endosome membrane / early endosome membrane / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / early endosome / endosome membrane / inflammatory response / innate immune response / Neutrophil degranulation / Golgi apparatus / endoplasmic reticulum / plasma membrane類似検索 - 分子機能 Transmembrane emp24 domain-containing protein / TIR domain / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics, simulated annealing |
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Model details | lowest energy, model1 |
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データ登録者 | Enokizono, Y. / Kumeta, H. / Funami, K. / Horiuchi, M. / Sarmiento, J. / Yamashita, K. / Standley, D.M. / Matsumoto, M. / Seya, T. / Inagaki, F. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2013 タイトル: Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. 著者: Enokizono, Y. / Kumeta, H. / Funami, K. / Horiuchi, M. / Sarmiento, J. / Yamashita, K. / Standley, D.M. / Matsumoto, M. / Seya, T. / Inagaki, F. |
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履歴 | 登録 | 2012年12月7日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2014年1月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年6月14日 | Group: Data collection / Database references / Other カテゴリ: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _struct_ref_seq_dif.details |
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改定 1.2 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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