Entry Database : PDB / ID : 2lsp Structure visualization Downloads & linksTitle solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide ComponentsBromodomain-containing protein 4 NF-kB-K310ac peptide DetailsKeywords PROTEIN BINDING / NF-kB / BRD4 / HIV / bromodomain / kidney diseaseFunction / homology Function and homology informationFunction Domain/homology Component
acetaldehyde metabolic process / prolactin signaling pathway / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / NF-kappaB p50/p65 complex / IkBA variant leads to EDA-ID / positive regulation of Schwann cell differentiation / cellular response to peptidoglycan / ankyrin repeat binding / RIP-mediated NFkB activation via ZBP1 / Regulated proteolysis of p75NTR ... acetaldehyde metabolic process / prolactin signaling pathway / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / NF-kappaB p50/p65 complex / IkBA variant leads to EDA-ID / positive regulation of Schwann cell differentiation / cellular response to peptidoglycan / ankyrin repeat binding / RIP-mediated NFkB activation via ZBP1 / Regulated proteolysis of p75NTR / SUMOylation of immune response proteins / CLEC7A/inflammasome pathway / negative regulation of protein sumoylation / defense response to tumor cell / postsynapse to nucleus signaling pathway / nucleotide-binding oligomerization domain containing 2 signaling pathway / cellular response to interleukin-6 / Interleukin-1 processing / negative regulation of non-canonical NF-kappaB signal transduction / actinin binding / cellular response to angiotensin / response to UV-B / NF-kappaB complex / positive regulation of leukocyte adhesion to vascular endothelial cell / Regulation of NFE2L2 gene expression / interleukin-1-mediated signaling pathway / vascular endothelial growth factor signaling pathway / positive regulation of miRNA metabolic process / non-canonical NF-kappaB signal transduction / toll-like receptor 4 signaling pathway / cellular response to hepatocyte growth factor stimulus / positive regulation of amyloid-beta formation / response to cobalamin / positive regulation of T cell receptor signaling pathway / phosphate ion binding / cellular response to lipoteichoic acid / response to muramyl dipeptide / TRAF6 mediated NF-kB activation / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / The NLRP3 inflammasome / general transcription initiation factor binding / P-TEFb complex binding / neuropeptide signaling pathway / Transcriptional Regulation by VENTX / NF-kappaB binding / hair follicle development / cellular response to interleukin-1 / positive regulation of vascular endothelial growth factor production / negative regulation by host of viral transcription / response to amino acid / RNA polymerase II core promoter sequence-specific DNA binding / cellular defense response / Purinergic signaling in leishmaniasis infection / canonical NF-kappaB signal transduction / positive regulation of T-helper 17 cell lineage commitment / antiviral innate immune response / negative regulation of insulin receptor signaling pathway / tumor necrosis factor-mediated signaling pathway / response to cAMP / positive regulation of G2/M transition of mitotic cell cycle / response to muscle stretch / histone reader activity / positive regulation of interleukin-12 production / CD209 (DC-SIGN) signaling / NF-kB is activated and signals survival / response to interleukin-1 / RNA polymerase II CTD heptapeptide repeat kinase activity / negative regulation of angiogenesis / negative regulation of miRNA transcription / liver development / condensed nuclear chromosome / positive regulation of interleukin-1 beta production / response to cytokine / positive regulation of interleukin-8 production / response to ischemia / response to progesterone / negative regulation of extrinsic apoptotic signaling pathway / Dectin-1 mediated noncanonical NF-kB signaling / positive regulation of transcription elongation by RNA polymerase II / RNA polymerase II transcription regulatory region sequence-specific DNA binding / animal organ morphogenesis / Activation of NF-kappaB in B cells / transcription coregulator activity / peptide binding / lysine-acetylated histone binding / TAK1-dependent IKK and NF-kappa-B activation / response to insulin / protein catabolic process / negative regulation of protein catabolic process / chromatin DNA binding / PKMTs methylate histone lysines / CLEC7A (Dectin-1) signaling / transcription coactivator binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / histone deacetylase binding / cytokine-mediated signaling pathway / positive regulation of miRNA transcription / FCERI mediated NF-kB activation / Transcriptional regulation of white adipocyte differentiation Similarity search - Function Transcription factor RelA (p65) / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. ... Transcription factor RelA (p65) / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. / Rel homology domain (RHD), DNA-binding domain superfamily / ig-like, plexins, transcription factors / IPT domain / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / p53-like transcription factor, DNA-binding / NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Immunoglobulin E-set / Immunoglobulin-like fold / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Homo Sapiens (human)Method SOLUTION NMR / DGSA-distance geometry simulated annealing , torsion angle dynamics DetailsAuthors Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. ...Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. / Ohlmeyer, M. / He, J. / Zhou, M.-M. CitationJournal : J.Biol.Chem. / Year : 2012Title : Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.Authors : Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Zeng, L. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. / Ohlmeyer, M. / He, J.C. / Zhou, M.M. History Deposition May 3, 2012 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Jul 18, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Aug 28, 2013 Group : Database referencesRevision 2.0 Nov 15, 2023 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations Category : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_spectrometer / struct_conn Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.model / _struct_conn.pdbx_leaving_atom_flag
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