登録情報 | データベース: PDB / ID: 2l53 |
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タイトル | Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac Sodium Channel NaV1.5 |
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要素 | - Calmodulin
- Voltage-gated sodium channel type V alpha isoform b variant
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キーワード | CA-BINDING PROTEIN/PROTON TRANSPORT / calmodulin / IQ motif / complex / Ca-Binding Protein / CA-BINDING PROTEIN-PROTON TRANSPORT complex |
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機能・相同性 | 機能・相同性情報
voltage-gated sodium channel activity involved in AV node cell action potential / voltage-gated sodium channel activity involved in bundle of His cell action potential / voltage-gated sodium channel activity involved in Purkinje myocyte action potential / voltage-gated sodium channel activity involved in SA node cell action potential / bundle of His cell action potential / regulation of ventricular cardiac muscle cell membrane depolarization / AV node cell action potential / SA node cell action potential / AV node cell to bundle of His cell communication / membrane depolarization during SA node cell action potential ...voltage-gated sodium channel activity involved in AV node cell action potential / voltage-gated sodium channel activity involved in bundle of His cell action potential / voltage-gated sodium channel activity involved in Purkinje myocyte action potential / voltage-gated sodium channel activity involved in SA node cell action potential / bundle of His cell action potential / regulation of ventricular cardiac muscle cell membrane depolarization / AV node cell action potential / SA node cell action potential / AV node cell to bundle of His cell communication / membrane depolarization during SA node cell action potential / transporter inhibitor activity / response to denervation involved in regulation of muscle adaptation / membrane depolarization during atrial cardiac muscle cell action potential / regulation of atrial cardiac muscle cell membrane repolarization / cardiac ventricle development / voltage-gated sodium channel activity involved in cardiac muscle cell action potential / brainstem development / membrane depolarization during AV node cell action potential / membrane depolarization during bundle of His cell action potential / atrial cardiac muscle cell action potential / membrane depolarization during Purkinje myocyte cell action potential / regulation of atrial cardiac muscle cell membrane depolarization / positive regulation of action potential / telencephalon development / cardiac conduction system development / : / : / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of ryanodine-sensitive calcium-release channel activity / : / positive regulation of protein autophosphorylation / membrane depolarization during cardiac muscle cell action potential / membrane depolarization during action potential / negative regulation of peptidyl-threonine phosphorylation / positive regulation of sodium ion transport / regulation of sodium ion transmembrane transport / ventricular cardiac muscle cell action potential / regulation of ventricular cardiac muscle cell membrane repolarization / establishment of protein localization to mitochondrial membrane / cardiac muscle cell action potential involved in contraction / type 3 metabotropic glutamate receptor binding / voltage-gated sodium channel complex / regulation of cardiac muscle cell contraction / Interaction between L1 and Ankyrins / positive regulation of peptidyl-threonine phosphorylation / ankyrin binding / voltage-gated sodium channel activity / positive regulation of DNA binding / negative regulation of high voltage-gated calcium channel activity / response to corticosterone / negative regulation of ryanodine-sensitive calcium-release channel activity / sodium ion transport / negative regulation of calcium ion export across plasma membrane / regulation of cardiac muscle cell action potential / presynaptic endocytosis / nitric-oxide synthase binding / regulation of cell communication by electrical coupling involved in cardiac conduction / Phase 0 - rapid depolarisation / regulation of synaptic vesicle exocytosis / calcineurin-mediated signaling / fibroblast growth factor binding / odontogenesis of dentin-containing tooth / regulation of heart rate by cardiac conduction / protein phosphatase activator activity / adenylate cyclase binding / lateral plasma membrane / intercalated disc / membrane depolarization / positive regulation of protein serine/threonine kinase activity / catalytic complex / regulation of synaptic vesicle endocytosis / detection of calcium ion / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / activation of adenylate cyclase activity / calcium channel inhibitor activity / phosphatidylinositol 3-kinase binding / presynaptic cytosol / cardiac muscle contraction / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / positive regulation of nitric-oxide synthase activity / titin binding / enzyme regulator activity / sperm midpiece / regulation of calcium-mediated signaling / voltage-gated potassium channel complex / calcium channel complex / T-tubule / substantia nigra development / sodium ion transmembrane transport / regulation of heart rate / calyx of Held / cellular response to calcium ion / adenylate cyclase activator activity / response to amphetamine / sarcomere / cerebellum development / regulation of cytokinesis / protein serine/threonine kinase activator activity / nitric-oxide synthase regulator activity類似検索 - 分子機能 Voltage gated sodium channel, alpha-5 subunit / Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Sodium ion transport-associated / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / SCN5A-like, C-terminal IQ motif / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Voltage-dependent channel domain superfamily ...Voltage gated sodium channel, alpha-5 subunit / Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Sodium ion transport-associated / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / SCN5A-like, C-terminal IQ motif / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Voltage-dependent channel domain superfamily / : / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Ion transport domain / Ion transport protein / EF-hand domain pair類似検索 - ドメイン・相同性 Calmodulin-2 / Calmodulin-3 / Sodium channel protein type 5 subunit alpha / Sodium channel protein type 5 subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / molecular dynamics |
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Model details | lowest energy, model 1 |
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データ登録者 | Chagot, B. / Chazin, W.J. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2011 タイトル: Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5. 著者: Chagot, B. / Chazin, W.J. |
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履歴 | 登録 | 2010年10月24日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2011年1月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq_dif.details |
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