Entry Database : PDB / ID : 4ey0 Structure visualization Downloads & linksTitle Structure of tandem SH2 domains from PLCgamma1 Components1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Details Keywords HYDROLASE / SH2 Domain / PLCgamma specific array / Interaction Domain / fibroblast growth factor receptor 1Function / homology Function and homology informationFunction Domain/homology Component
Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / Role of second messengers in netrin-1 signaling / PLC-gamma1 signalling / phosphoinositide phospholipase C / DAG and IP3 signaling / phospholipid catabolic process / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR3 ... Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / Role of second messengers in netrin-1 signaling / PLC-gamma1 signalling / phosphoinositide phospholipase C / DAG and IP3 signaling / phospholipid catabolic process / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR2 / phosphatidylinositol phospholipase C activity / Phospholipase C-mediated cascade; FGFR4 / Erythropoietin activates Phospholipase C gamma (PLCG) / COP9 signalosome / Phospholipase C-mediated cascade: FGFR1 / phospholipase C activity / neurotrophin TRKA receptor binding / positive regulation of endothelial cell apoptotic process / phosphatidylinositol-mediated signaling / EGFR interacts with phospholipase C-gamma / positive regulation of vascular endothelial cell proliferation / PLCG1 events in ERBB2 signaling / Signaling by ALK / positive regulation of epithelial cell migration / Synthesis of IP3 and IP4 in the cytosol / Fc-epsilon receptor signaling pathway / PECAM1 interactions / Generation of second messenger molecules / Signaling by ALK fusions and activated point mutants / RET signaling / glutamate receptor binding / positive regulation of blood vessel endothelial cell migration / Role of phospholipids in phagocytosis / Signaling by FGFR4 in disease / release of sequestered calcium ion into cytosol / negative regulation of inflammatory response to antigenic stimulus / Signaling by FGFR3 in disease / cellular response to epidermal growth factor stimulus / ruffle / Signaling by FGFR2 in disease / Signaling by FGFR1 in disease / Downstream signal transduction / FCERI mediated Ca+2 mobilization / guanyl-nucleotide exchange factor activity / FCGR3A-mediated IL10 synthesis / positive regulation of release of sequestered calcium ion into cytosol / VEGFR2 mediated cell proliferation / cell projection / calcium-mediated signaling / FCERI mediated MAPK activation / Signaling by ERBB2 TMD/JMD mutants / modulation of chemical synaptic transmission / Schaffer collateral - CA1 synapse / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / epidermal growth factor receptor signaling pathway / Signaling by ERBB2 KD Mutants / receptor tyrosine kinase binding / ISG15 antiviral mechanism / ruffle membrane / positive regulation of angiogenesis / cell-cell junction / cell migration / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / DAP12 signaling / lamellipodium / T cell receptor signaling pathway / in utero embryonic development / glutamatergic synapse / calcium ion binding / protein kinase binding / plasma membrane / cytosol / cytoplasm Similarity search - Function 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase X-box domain profile. ... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase X-box domain profile. / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / SH2 domain / C2 domain / Protein kinase C conserved region 2 (CalB) / SHC Adaptor Protein / C2 domain / C2 domain profile. / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / SH2 domain superfamily / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain / EF-hand domain pair / PH-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Cole, A.R. / Mas-Droux, C.P. / Bunney, T.D. / Katan, M. CitationJournal : Structure / Year : 2012Title : Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.Authors : Bunney, T.D. / Esposito, D. / Mas-Droux, C. / Lamber, E. / Baxendale, R.W. / Martins, M. / Cole, A. / Svergun, D. / Driscoll, P.C. / Katan, M. History Deposition May 1, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 31, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Jun 19, 2013 Group : Database references
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