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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 2l34 | ||||||
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タイトル | Structure of the DAP12 transmembrane homodimer | ||||||
![]() | TYRO protein tyrosine kinase-binding protein | ||||||
![]() | PROTEIN BINDING / Immunoreceptor / transmembrane assembly / DAP12 | ||||||
機能・相同性 | ![]() myeloid leukocyte activation / stimulatory killer cell immunoglobulin-like receptor signaling pathway / positive regulation of receptor localization to synapse / positive regulation of macrophage fusion / positive regulation of osteoclast development / microglial cell activation involved in immune response / positive regulation of natural killer cell activation / negative regulation of transforming growth factor beta1 production / Other semaphorin interactions / positive regulation of microglial cell mediated cytotoxicity ...myeloid leukocyte activation / stimulatory killer cell immunoglobulin-like receptor signaling pathway / positive regulation of receptor localization to synapse / positive regulation of macrophage fusion / positive regulation of osteoclast development / microglial cell activation involved in immune response / positive regulation of natural killer cell activation / negative regulation of transforming growth factor beta1 production / Other semaphorin interactions / positive regulation of microglial cell mediated cytotoxicity / neutrophil activation involved in immune response / positive regulation of protein localization to cell surface / apoptotic cell clearance / Signal regulatory protein family interactions / negative regulation of type I interferon production / negative regulation of interleukin-10 production / negative regulation of B cell proliferation / stimulatory C-type lectin receptor signaling pathway / negative regulation of long-term synaptic potentiation / response to axon injury / cellular defense response / forebrain development / osteoclast differentiation / positive regulation of superoxide anion generation / secretory granule membrane / positive regulation of interleukin-1 beta production / DAP12 interactions / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / DAP12 signaling / actin cytoskeleton organization / molecular adaptor activity / protein stabilization / intracellular signal transduction / signaling receptor binding / Neutrophil degranulation / positive regulation of gene expression / cell surface / signal transduction / protein homodimerization activity / identical protein binding / membrane / metal ion binding / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR / simulated annealing, molecular dynamics | ||||||
Model details | lowest energy, model 1 | ||||||
![]() | Call, M.E. / Wucherpfennig, K.W. / Chou, J.J. | ||||||
![]() | ![]() タイトル: The structural basis for intramembrane assembly of an activating immunoreceptor complex. 著者: Call, M.E. / Wucherpfennig, K.W. / Chou, J.J. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 287.5 KB | 表示 | ![]() |
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PDB形式 | ![]() | 249.4 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 350.3 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 491.9 KB | 表示 | |
XML形式データ | ![]() | 16.3 KB | 表示 | |
CIF形式データ | ![]() | 27.5 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質・ペプチド | 分子量: 3331.042 Da / 分子数: 2 / 断片: UNP RESIDUES 35-67 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||||||||||||||||||
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NMR実験 |
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試料調製
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試料状態 | イオン強度: 20 / pH: 6.8 / 圧: ambient / 温度: 303 K |
-NMR測定
NMRスペクトロメーター | タイプ: Bruker Avance / 製造業者: Bruker / モデル: Avance / 磁場強度: 600 MHz |
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解析
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精密化 | 手法: simulated annealing, molecular dynamics / ソフトェア番号: 1 | |||||||||||||||||||||
代表構造 | 選択基準: lowest energy | |||||||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: structures with the lowest energy 計算したコンフォーマーの数: 75 / 登録したコンフォーマーの数: 15 / 代表コンフォーマー: 1 |