登録情報 | データベース: PDB / ID: 2l1m |
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タイトル | Solution structure of the eag domain of the hERG (Kv11.1) K+ channel |
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要素 | Potassium voltage-gated channel subfamily H member 2 |
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キーワード | TRANSPORT PROTEIN (運搬体タンパク質) / eag domain / hERG (HERG) / Kv11.1 / PAS domain |
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機能・相同性 | 機能・相同性情報
inward rectifier potassium channel complex / negative regulation of potassium ion export across plasma membrane / regulation of heart rate by hormone / Phase 3 - rapid repolarisation / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / membrane repolarization during ventricular cardiac muscle cell action potential / negative regulation of potassium ion transmembrane transport / membrane repolarization during cardiac muscle cell action potential / potassium ion export across plasma membrane ... inward rectifier potassium channel complex / negative regulation of potassium ion export across plasma membrane / regulation of heart rate by hormone / Phase 3 - rapid repolarisation / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / membrane repolarization during ventricular cardiac muscle cell action potential / negative regulation of potassium ion transmembrane transport / membrane repolarization during cardiac muscle cell action potential / potassium ion export across plasma membrane / C3HC4-type RING finger domain binding / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / regulation of membrane repolarization / membrane repolarization / positive regulation of potassium ion transmembrane transport / Voltage gated Potassium channels / inward rectifier potassium channel activity / potassium ion homeostasis / ventricular cardiac muscle cell action potential / delayed rectifier potassium channel activity / membrane depolarization during action potential / regulation of potassium ion transmembrane transport / regulation of ventricular cardiac muscle cell membrane repolarization / potassium ion import across plasma membrane / voltage-gated potassium channel activity / regulation of heart rate by cardiac conduction / cardiac muscle contraction / potassium ion transmembrane transport / voltage-gated potassium channel complex / regulation of membrane potential / cellular response to xenobiotic stimulus / scaffold protein binding / transcription cis-regulatory region binding / ubiquitin protein ligase binding / perinuclear region of cytoplasm / positive regulation of DNA-templated transcription / 細胞膜 / protein homodimerization activity / identical protein binding / 細胞膜類似検索 - 分子機能 Potassium channel, voltage-dependent, ERG / Potassium channel, voltage-dependent, EAG/ELK/ERG / PAS-associated, C-terminal / PAS domain / PAC domain profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain ... Potassium channel, voltage-dependent, ERG / Potassium channel, voltage-dependent, EAG/ELK/ERG / PAS-associated, C-terminal / PAS domain / PAC domain profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / Β-ラクタマーゼ / PAS repeat profile. / PAS domain / RmlC-like jelly roll fold / PAS domain superfamily / Ion transport domain / Ion transport protein / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性Potassium voltage-gated channel subfamily H member 2類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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Model details | lowest energy, model 1 |
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データ登録者 | Muskett, F.W. / Mitcheson, J.S. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2011 タイトル: Mechanistic insight into human ether-a-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain. 著者: Muskett, F.W. / Thouta, S. / Thomson, S.J. / Bowen, A. / Stansfeld, P.J. / Mitcheson, J.S. |
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履歴 | 登録 | 2010年7月29日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2011年1月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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