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Open data
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Basic information
Entry | Database: PDB / ID: 2ky3 | ||||||
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Title | Solution structure of GS-alfa-Ktx5.4 synthetic scorpion like | ||||||
![]() | Potassium channel toxin alpha-KTx 5.4 | ||||||
![]() | TOXIN / alpha/beta scaffold / beta sheet / alpha helix / scoprion K+ toxin / GS-alpha-Ktx5.4 / aKtx5.4 / Mesobuthus tamulus / potassium blocker | ||||||
Function / homology | Scorpion short toxins signature. / Scorpion short chain toxin, potassium channel inhibitor / Scorpion short toxin, BmKK2 / Knottin, scorpion toxin-like superfamily / ion channel inhibitor activity / potassium channel regulator activity / toxin activity / extracellular region / Potassium channel toxin alpha-KTx 5.4![]() | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / TORSION ANGLE DYNAMICS, MOLECULAR DYNAMICS | ||||||
Model details | lowest energy, model 1 | ||||||
![]() | Del Rio-Portilla, F. / Ramirez-Cordero, B.E. / Brieba-De Castro, L. | ||||||
![]() | ![]() Title: Cytotoxicity of recombinant tamapin and related toxin-like peptides on model cell lines. Authors: Ramirez-Cordero, B. / Toledano, Y. / Cano-Sanchez, P. / Hernandez-Lopez, R. / Flores-Solis, D. / Saucedo-Yanez, A.L. / Chavez-Uribe, I. / Brieba, L.G. / Del Rio-Portilla, F. #1: Journal: J.Biol.Chem. / Year: 2002 Title: Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. Authors: Pedarzani, P. / D'hoedt, D. / Doorty, K.B. / Wadsworth, J.D. / Joseph, J.S. / Jeyaseelan, K. / Kini, R.M. / Gadre, S.V. / Sapatnekar, S.M. / Stocker, M. / Strong, P.N. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 164.1 KB | Display | ![]() |
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PDB format | ![]() | 144 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 391.2 KB | Display | ![]() |
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Full document | ![]() | 458.4 KB | Display | |
Data in XML | ![]() | 10.6 KB | Display | |
Data in CIF | ![]() | 17.5 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2lu9C ![]() 2me7C ![]() 2melC ![]() 2menC ![]() 2meoC C: citing same article ( |
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Similar structure data | |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 3614.315 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() Production host: ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||
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NMR experiment |
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Sample preparation
Details | Contents: 1.8 mM GS-alfa-Ktx5.4 SCORPION TOXIN, 95% H2O/5% D2O Solvent system: 95% H2O/5% D2O |
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Sample | Conc.: 1.8 mM / Component: GS-alfa-Ktx5.4 SCORPION TOXIN-1 |
Sample conditions | pH: 6.5 / Pressure: AMBIENT / Temperature: 297 K |
-NMR measurement
NMR spectrometer |
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Processing
NMR software |
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Refinement | Method: TORSION ANGLE DYNAMICS, MOLECULAR DYNAMICS / Software ordinal: 1 | ||||||||||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||||||||||
NMR ensemble | Conformer selection criteria: target function / Conformers calculated total number: 200 / Conformers submitted total number: 17 |