登録情報 | データベース: PDB / ID: 2krg |
---|
タイトル | Solution Structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) |
---|
要素 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
---|
キーワード | SIGNALING PROTEIN / Acetylation / Cell projection / Disease mutation / Membrane / Phosphoprotein / Polymorphism / Wnt signaling pathway |
---|
機能・相同性 | 機能・相同性情報
import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import ...import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / cerebrospinal fluid circulation / microvillus assembly / positive regulation of monoatomic ion transmembrane transport / negative regulation of sodium ion transport / bile acid secretion / maintenance of epithelial cell apical/basal polarity / plasma membrane organization / stereocilium tip / cilium organization / intracellular phosphate ion homeostasis / gland morphogenesis / myosin II binding / phospholipase C-activating dopamine receptor signaling pathway / growth factor receptor binding / establishment of Golgi localization / fibroblast migration / type 3 metabotropic glutamate receptor binding / plasma membrane protein complex / establishment of epithelial cell apical/basal polarity / negative regulation of fibroblast migration / chloride channel regulator activity / negative regulation of platelet-derived growth factor receptor signaling pathway / auditory receptor cell stereocilium organization / nuclear migration / regulation of protein kinase activity / microvillus membrane / regulation of cell size / renal absorption / microvillus / transport across blood-brain barrier / negative regulation of mitotic cell cycle / phosphatase binding / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endomembrane system / beta-2 adrenergic receptor binding / positive regulation of intrinsic apoptotic signaling pathway / protein-membrane adaptor activity / sperm midpiece / ruffle / filopodium / cell periphery / protein localization to plasma membrane / PDZ domain binding / morphogenesis of an epithelium / brush border membrane / sensory perception of sound / negative regulation of canonical Wnt signaling pathway / negative regulation of ERK1 and ERK2 cascade / beta-catenin binding / Wnt signaling pathway / adenylate cyclase-activating dopamine receptor signaling pathway / : / actin cytoskeleton / regulation of cell shape / actin cytoskeleton organization / protein-containing complex assembly / vesicle / transmembrane transporter binding / apical plasma membrane / negative regulation of cell population proliferation / signaling receptor binding / protein-containing complex binding / perinuclear region of cytoplasm / extracellular exosome / identical protein binding / membrane / cytoplasm類似検索 - 分子機能 EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily ...EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Na(+)/H(+) exchange regulatory cofactor NHE-RF1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 溶液NMR / torsion angle dynamics, simulated annealing |
---|
データ登録者 | Bhattacharya, S. / Dai, Z. / Li, J. / Baxter, S. / Callaway, D.J.E. / Cowburn, D. / Bu, Z. |
---|
引用 | ジャーナル: J.Biol.Chem. / 年: 2010 タイトル: A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation. 著者: Bhattacharya, S. / Dai, Z. / Li, J. / Baxter, S. / Callaway, D.J.E. / Cowburn, D. / Bu, Z. |
---|
履歴 | 登録 | 2009年12月17日 | 登録サイト: BMRB / 処理サイト: RCSB |
---|
改定 1.0 | 2009年12月29日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.2 | 2022年3月16日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
---|
改定 1.3 | 2023年7月26日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name |
---|
改定 1.4 | 2024年5月22日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|