登録情報 | データベース: PDB / ID: 2k2q |
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タイトル | complex structure of the external thioesterase of the Surfactin-synthetase with a carrier domain |
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要素 | - Surfactin synthetase thioesterase subunit
- Tyrocidine synthetase 3 (Tyrocidine synthetase III)
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キーワード | Ligase/Hydrolase / thioesterase / a/b-hydrolase / NRPS / non-ribosomal peptide synthetase / type II thioesterase / Antibiotic biosynthesis / Ligase / Multifunctional enzyme / Phosphopantetheine / Sporulation / Stress response / Ligase-Hydrolase COMPLEX |
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機能・相同性 | 機能・相同性情報
amino acid activation for nonribosomal peptide biosynthetic process / 加水分解酵素; エステル加水分解酵素; 3価のアルコールのエステル加水分解酵素 / carboxylic acid metabolic process / secondary metabolite biosynthetic process / lipid biosynthetic process / sporulation resulting in formation of a cellular spore / ligase activity / phosphopantetheine binding / antibiotic biosynthetic process / hydrolase activity ...amino acid activation for nonribosomal peptide biosynthetic process / 加水分解酵素; エステル加水分解酵素; 3価のアルコールのエステル加水分解酵素 / carboxylic acid metabolic process / secondary metabolite biosynthetic process / lipid biosynthetic process / sporulation resulting in formation of a cellular spore / ligase activity / phosphopantetheine binding / antibiotic biosynthetic process / hydrolase activity / cytoplasm / cytosol類似検索 - 分子機能 Thioesterase type II, NRPS/PKS/S-FAS / ACP-like / PKS_PP_betabranch / Thioesterase / Thioesterase domain / Condensation domain / Condensation domain / Amino acid adenylation domain / Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A / AMP-binding enzyme, C-terminal domain ...Thioesterase type II, NRPS/PKS/S-FAS / ACP-like / PKS_PP_betabranch / Thioesterase / Thioesterase domain / Condensation domain / Condensation domain / Amino acid adenylation domain / Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A / AMP-binding enzyme, C-terminal domain / AMP-binding enzyme C-terminal domain / Chloramphenicol acetyltransferase-like domain superfamily / AMP-binding, conserved site / Putative AMP-binding domain signature. / Polyketide synthase, phosphopantetheine-binding domain / Phosphopantetheine attachment site / AMP-dependent synthetase/ligase / AMP-binding enzyme, C-terminal domain superfamily / AMP-binding enzyme / Phosphopantetheine attachment site / Phosphopantetheine attachment site. / Phosphopantetheine attachment site / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domain / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Tyrocidine synthase 3 / Surfactin synthase thioesterase subunit類似検索 - 構成要素 |
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生物種 | Brevibacillus parabrevis (バクテリア)
![](img/tx_bacteria.gif) Bacillus subtilis (枯草菌) |
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手法 | 溶液NMR / simulated annealing |
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Model details | heterodimeric NMR solution structure of SrfTEII and TycC3-PCP |
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データ登録者 | Koglin, A. / Lohr, F. / Bernhard, F. / Rogov, V.V. / Frueh, D.P. / Strieter, E.R. / Mofid, M.R. / Guntert, P. / Wagner, G. / Walsh, C.T. ...Koglin, A. / Lohr, F. / Bernhard, F. / Rogov, V.V. / Frueh, D.P. / Strieter, E.R. / Mofid, M.R. / Guntert, P. / Wagner, G. / Walsh, C.T. / Marahiel, M.A. / Dotsch, V. |
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引用 | ジャーナル: Nature / 年: 2008 タイトル: Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. 著者: Koglin, A. / Lohr, F. / Bernhard, F. / Rogov, V.V. / Frueh, D.P. / Strieter, E.R. / Mofid, M.R. / Guntert, P. / Wagner, G. / Walsh, C.T. / Marahiel, M.A. / Dotsch, V. |
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履歴 | 登録 | 2008年4月10日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2008年12月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2016年10月19日 | Group: Structure summary |
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改定 1.3 | 2018年1月24日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
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改定 1.4 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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