Entry Database : PDB / ID : 2js7 Structure visualization Downloads & linksTitle Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A ComponentsMyeloid differentiation primary response protein MyD88 Details Keywords SIGNALING PROTEIN / MYD88_HUMAN / TIR DOMAIN / TOLL LIKE RECEPTOR ADAPTOR DOMAIN / innate immune signaling / Structural Genomics / PSI-2 / Protein Structure Initiative / Northeast Structural Genomics Consortium / NESGFunction / homology Function and homology informationFunction Domain/homology Component
regulation of chemokine (C-X-C motif) ligand 1 production / MyD88 deficiency (TLR5) / regulation of chemokine (C-X-C motif) ligand 2 production / ATP-dependent histone chaperone activity / Toll binding / toll-like receptor 5 signaling pathway / induced systemic resistance / neutrophil-mediated killing of bacterium / leukocyte activation involved in inflammatory response / TIR domain binding ... regulation of chemokine (C-X-C motif) ligand 1 production / MyD88 deficiency (TLR5) / regulation of chemokine (C-X-C motif) ligand 2 production / ATP-dependent histone chaperone activity / Toll binding / toll-like receptor 5 signaling pathway / induced systemic resistance / neutrophil-mediated killing of bacterium / leukocyte activation involved in inflammatory response / TIR domain binding / response to molecule of fungal origin / toll-like receptor 8 signaling pathway / response to peptidoglycan / positive regulation of lymphocyte proliferation / establishment of endothelial intestinal barrier / positive regulation of interleukin-23 production / MyD88 dependent cascade initiated on endosome / IRAK4 deficiency (TLR5) / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / regulation of neutrophil migration / MyD88 cascade initiated on plasma membrane / toll-like receptor TLR6:TLR2 signaling pathway / Toll signaling pathway / cellular response to oxidised low-density lipoprotein particle stimulus / Toll-like receptor binding / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / interleukin-33-mediated signaling pathway / neutrophil activation involved in immune response / interleukin-1 receptor binding / microglia differentiation / RIP-mediated NFkB activation via ZBP1 / positive regulation of cytokine production involved in inflammatory response / death receptor binding / MyD88 deficiency (TLR2/4) / interleukin-1-mediated signaling pathway / MyD88-dependent toll-like receptor signaling pathway / positive regulation of macrophage cytokine production / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / 3'-UTR-mediated mRNA stabilization / extrinsic component of plasma membrane / positive regulation of NLRP3 inflammasome complex assembly / skin development / type I interferon-mediated signaling pathway / defense response to protozoan / response to amine / extrinsic component of cytoplasmic side of plasma membrane / positive regulation of interleukin-17 production / positive regulation of type I interferon production / response to amino acid / immunoglobulin mediated immune response / phagocytosis / lipopolysaccharide-mediated signaling pathway / signaling adaptor activity / positive regulation of chemokine production / JNK cascade / p75NTR recruits signalling complexes / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / response to interleukin-1 / positive regulation of interleukin-1 beta production / positive regulation of interleukin-8 production / positive regulation of JNK cascade / positive regulation of smooth muscle cell proliferation / response to organic cyclic compound / cellular response to mechanical stimulus / Interleukin-1 signaling / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / PIP3 activates AKT signaling / positive regulation of NF-kappaB transcription factor activity / ER-Phagosome pathway / regulation of inflammatory response / gene expression / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / defense response to virus / positive regulation of canonical NF-kappaB signal transduction / response to ethanol / molecular adaptor activity / cell surface receptor signaling pathway / endosome membrane / defense response to Gram-positive bacterium / defense response to bacterium / innate immune response / positive regulation of gene expression / apoptotic process / cell surface / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / identical protein binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Myeloid differentiation primary response protein MyD88 / MyD88, death domain / Toll/interleukin-1 receptor homology (TIR) domain / TIR domain / TIR domain / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Toll - interleukin 1 - resistance ... Myeloid differentiation primary response protein MyD88 / MyD88, death domain / Toll/interleukin-1 receptor homology (TIR) domain / TIR domain / TIR domain / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Toll - interleukin 1 - resistance / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Death-like domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / simulated annealing DetailsAuthors Rossi, P. / Ramelot, T.A. / Tao, X. / Ciano, M. / Ho, C. / Ma, L.-C. / Xiao, R. / Acton, T.B. / Kennedy, M.A. / Tong, L. ...Rossi, P. / Ramelot, T.A. / Tao, X. / Ciano, M. / Ho, C. / Ma, L.-C. / Xiao, R. / Acton, T.B. / Kennedy, M.A. / Tong, L. / Montelione, G.T. / Northeast Structural Genomics Consortium (NESG) CitationJournal : To be Published Title : Solution NMR Structure of Human Myeloid Differentiation Primary Response (MyD88).Authors : Rossi, P. / Xiao, R. / Tao, X. / Acton, T.B. / Tong, L. / Montelione, G.T. History Deposition Jun 29, 2007 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Oct 23, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Jun 27, 2012 Group : Structure summaryRevision 1.3 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.4 Feb 19, 2020 Group : Data collection / Database references / OtherCategory : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _pdbx_nmr_software.name ... _pdbx_database_status.status_code_cs / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details Revision 1.5 Oct 30, 2024 Group : Data collection / Database references / Structure summaryCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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