PROTEIN TRANSPORT / CHMP2B / VPS4B MIT / Complex / Four Helix Bundle
Function / homology
Function and homology information
: / protein depolymerization / intracellular anatomical structure / positive regulation of centriole elongation / ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway / negative regulation of exosomal secretion / late endosome to lysosome transport via multivesicular body sorting pathway / multivesicular body-lysosome fusion / ESCRT III complex disassembly / ESCRT III complex ...: / protein depolymerization / intracellular anatomical structure / positive regulation of centriole elongation / ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway / negative regulation of exosomal secretion / late endosome to lysosome transport via multivesicular body sorting pathway / multivesicular body-lysosome fusion / ESCRT III complex disassembly / ESCRT III complex / late endosomal microautophagy / endosome transport via multivesicular body sorting pathway / regulation of centrosome duplication / nuclear membrane reassembly / Sealing of the nuclear envelope (NE) by ESCRT-III / endosome organization / midbody abscission / establishment of blood-brain barrier / multivesicular body sorting pathway / vacuole organization / membrane fission / plasma membrane repair / late endosome to vacuole transport / positive regulation of exosomal secretion / ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / multivesicular body assembly / regulation of mitotic spindle assembly / regulation of modification of postsynaptic structure / endosome to lysosome transport via multivesicular body sorting pathway / cholesterol transport / vesicle-fusing ATPase / Flemming body / endosomal transport / mitotic metaphase chromosome alignment / Macroautophagy / response to lipid / ATPase complex / nucleus organization / viral budding via host ESCRT complex / autophagosome maturation / canonical Wnt signaling pathway / nuclear pore / Endosomal Sorting Complex Required For Transport (ESCRT) / viral life cycle / positive regulation of G2/M transition of mitotic cell cycle / multivesicular body / viral budding from plasma membrane / HCMV Late Events / macroautophagy / Late endosomal microautophagy / potassium ion transport / Budding and maturation of HIV virion / cognition / autophagy / spindle pole / neuron cellular homeostasis / protein transport / late endosome membrane / midbody / angiogenesis / endosome membrane / endosome / cadherin binding / protein domain specific binding / centrosome / glutamatergic synapse / protein-containing complex binding / protein homodimerization activity / ATP hydrolysis activity / extracellular exosome / ATP binding / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function
Vacuolar protein sorting-associated protein 4, MIT domain / Phosphotransferase system, lactose/cellobiose-type IIA subunit / MIT (microtubule interacting and transport) domain / MIT domain superfamily / Vps4 oligomerisation, C-terminal / MIT domain / Microtubule Interacting and Trafficking molecule domain / Snf7 family / Snf7 / Vps4 C terminal oligomerisation domain ...Vacuolar protein sorting-associated protein 4, MIT domain / Phosphotransferase system, lactose/cellobiose-type IIA subunit / MIT (microtubule interacting and transport) domain / MIT domain superfamily / Vps4 oligomerisation, C-terminal / MIT domain / Microtubule Interacting and Trafficking molecule domain / Snf7 family / Snf7 / Vps4 C terminal oligomerisation domain / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / Mainly Alpha Similarity search - Domain/homology
Vacuolar protein sorting-associated protein 4B / Charged multivesicular body protein 2b Similarity search - Component
Method: simulated annealing / Software ordinal: 1 Details: Refinement using anneal.inp and using summed NOE constraints with max T of 3000 K for simulated annealing.
NMR constraints
NOE constraints total: 1586 / NOE intraresidue total count: 400 / NOE long range total count: 465 / NOE medium range total count: 417 / NOE sequential total count: 394 / Hydrogen bond constraints total count: 61 / Protein chi angle constraints total count: 0 / Protein other angle constraints total count: 0 / Protein phi angle constraints total count: 70 / Protein psi angle constraints total count: 70
NMR representative
Selection criteria: lowest energy
NMR ensemble
Average torsion angle constraint violation: 0.08 ° Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 200 / Conformers submitted total number: 20 / Maximum lower distance constraint violation: 0 Å / Maximum torsion angle constraint violation: 0.1 ° / Maximum upper distance constraint violation: 0.024 Å / Torsion angle constraint violation method: CNS
NMR ensemble rms
Distance rms dev: 0.005 Å
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