- PDB-2hxm: Complex of UNG2 and a small Molecule synthetic Inhibitor -
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基本情報
登録情報
データベース: PDB / ID: 2hxm
タイトル
Complex of UNG2 and a small Molecule synthetic Inhibitor
要素
Uracil-DNA glycosylase
キーワード
HYDROLASE / DNA REPAIR / URACIL / URACIL DNA GLYCOSYLASE
機能・相同性
機能・相同性情報
base-excision repair, AP site formation via deaminated base removal / uracil-DNA glycosylase / depyrimidination / Displacement of DNA glycosylase by APEX1 / isotype switching / uracil DNA N-glycosylase activity / ribosomal small subunit binding / somatic hypermutation of immunoglobulin genes / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine ...base-excision repair, AP site formation via deaminated base removal / uracil-DNA glycosylase / depyrimidination / Displacement of DNA glycosylase by APEX1 / isotype switching / uracil DNA N-glycosylase activity / ribosomal small subunit binding / somatic hypermutation of immunoglobulin genes / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Chromatin modifications during the maternal to zygotic transition (MZT) / base-excision repair / damaged DNA binding / negative regulation of apoptotic process / mitochondrion / nucleoplasm / nucleus 類似検索 - 分子機能
Uracil-DNA glycosylase family 1 / UreE urease accessory protein, C-terminal domain / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase, active site / Uracil-DNA glycosylase signature. / Uracil-DNA Glycosylase, subunit E / Uracil-DNA glycosylase-like domain / Uracil-DNA glycosylase-like / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase-like domain superfamily ...Uracil-DNA glycosylase family 1 / UreE urease accessory protein, C-terminal domain / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase, active site / Uracil-DNA glycosylase signature. / Uracil-DNA Glycosylase, subunit E / Uracil-DNA glycosylase-like domain / Uracil-DNA glycosylase-like / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase-like domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
COMPOUND THE SMALL MOLECULE COMPOUND WAS SYNTHESIZED USING A NOVEL HIGH-THROUGHPUT TECHNIQUE TO ...COMPOUND THE SMALL MOLECULE COMPOUND WAS SYNTHESIZED USING A NOVEL HIGH-THROUGHPUT TECHNIQUE TO PRODUCE URACIL TETHERED INHIBITORS OF UNG2. REMARKABLY, THIS INHIBITOR MIMICS THE CRUCIAL HYDROGEN BONDING AND ELECTROSTATIC OBSERVED IN UNG2-DAMAGED DNA COMPLEXES.