登録情報 | データベース: PDB / ID: 2hl5 |
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タイトル | Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued) |
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要素 | - Dynactin-1
- Microtubule-associated protein RP/EB family member 1
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キーワード | STRUCTURAL PROTEIN / microtubule binding / dynactin / cytoskeleton associated protein / p150Glued / EB1 / +TIP protein Complex structure |
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機能・相同性 | 機能・相同性情報
centriolar subdistal appendage / positive regulation of neuromuscular junction development / centriole-centriole cohesion / cell cortex region / protein localization to astral microtubule / cortical microtubule cytoskeleton / microtubule anchoring at centrosome / ventral spinal cord development / mitotic spindle astral microtubule end / maintenance of synapse structure ...centriolar subdistal appendage / positive regulation of neuromuscular junction development / centriole-centriole cohesion / cell cortex region / protein localization to astral microtubule / cortical microtubule cytoskeleton / microtubule anchoring at centrosome / ventral spinal cord development / mitotic spindle astral microtubule end / maintenance of synapse structure / melanosome transport / protein localization to microtubule / nuclear membrane disassembly / microtubule plus-end / positive regulation of microtubule nucleation / cell projection membrane / XBP1(S) activates chaperone genes / dynein complex / attachment of mitotic spindle microtubules to kinetochore / COPI-independent Golgi-to-ER retrograde traffic / microtubule plus-end binding / non-motile cilium assembly / microtubule bundle formation / retrograde transport, endosome to Golgi / nuclear migration / protein localization to centrosome / motor behavior / microtubule organizing center / microtubule associated complex / neuromuscular process / negative regulation of microtubule polymerization / neuromuscular junction development / intercellular bridge / mitotic spindle pole / cytoplasmic microtubule / cell leading edge / establishment of mitotic spindle orientation / microtubule polymerization / regulation of microtubule polymerization or depolymerization / spindle assembly / spindle midzone / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / COPI-mediated anterograde transport / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / regulation of mitotic spindle organization / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / positive regulation of microtubule polymerization / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / Resolution of Sister Chromatid Cohesion / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / neuron projection maintenance / MHC class II antigen presentation / centriole / tubulin binding / AURKA Activation by TPX2 / ciliary basal body / RHO GTPases Activate Formins / tau protein binding / mitotic spindle / kinetochore / spindle pole / spindle / neuron cellular homeostasis / Separation of Sister Chromatids / The role of GTSE1 in G2/M progression after G2 checkpoint / microtubule cytoskeleton / Regulation of PLK1 Activity at G2/M Transition / protein localization / Signaling by ALK fusions and activated point mutants / cell migration / nuclear envelope / mitotic cell cycle / nervous system development / cell cortex / microtubule binding / microtubule / neuron projection / cadherin binding / cell division / axon / focal adhesion / centrosome / neuronal cell body / protein kinase binding / Golgi apparatus / RNA binding / identical protein binding / membrane / cytosol / cytoplasm類似検索 - 分子機能 Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #1430 / Dynein associated protein / Dynein associated protein / CAP Gly-rich-like domain / EB1, C-terminal / Microtubule-associated protein RP/EB / EB1, C-terminal domain superfamily / EB1-C terminal (EB1-C) domain profile. / EB1-like C-terminal motif / CAP-Gly domain signature. ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #1430 / Dynein associated protein / Dynein associated protein / CAP Gly-rich-like domain / EB1, C-terminal / Microtubule-associated protein RP/EB / EB1, C-terminal domain superfamily / EB1-C terminal (EB1-C) domain profile. / EB1-like C-terminal motif / CAP-Gly domain signature. / CAP Gly-rich domain / CAP Gly-rich domain superfamily / CAP-Gly domain / CAP-Gly domain profile. / CAP_GLY / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / SH3 type barrels. / Roll / Up-down Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 Dynactin subunit 1 / Microtubule-associated protein RP/EB family member 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.93 Å |
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データ登録者 | Honnappa, S. / Winkler, F.K. / Steinmetz, M.O. |
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引用 | ジャーナル: Mol.Cell / 年: 2006 タイトル: Key interaction modes of dynamic +TIP networks. 著者: Honnappa, S. / Okhrimenko, O. / Jaussi, R. / Jawhari, H. / Jelesarov, I. / Winkler, F.K. / Steinmetz, M.O. |
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履歴 | 登録 | 2006年7月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年9月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.3 | 2021年10月20日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2024年2月14日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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