- PDB-2hl5: Crystal structure of the C-terminal domain of human EB1 in comple... -
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Basic information
Entry
Database: PDB / ID: 2hl5
Title
Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued)
Components
Dynactin-1
Microtubule-associated protein RP/EB family member 1
Keywords
STRUCTURAL PROTEIN / microtubule binding / dynactin / cytoskeleton associated protein / p150Glued / EB1 / +TIP protein Complex structure
Function / homology
Function and homology information
centriolar subdistal appendage / positive regulation of neuromuscular junction development / centriole-centriole cohesion / cell cortex region / protein localization to astral microtubule / cortical microtubule cytoskeleton / microtubule anchoring at centrosome / ventral spinal cord development / mitotic spindle astral microtubule end / maintenance of synapse structure ...centriolar subdistal appendage / positive regulation of neuromuscular junction development / centriole-centriole cohesion / cell cortex region / protein localization to astral microtubule / cortical microtubule cytoskeleton / microtubule anchoring at centrosome / ventral spinal cord development / mitotic spindle astral microtubule end / maintenance of synapse structure / melanosome transport / protein localization to microtubule / nuclear membrane disassembly / microtubule plus-end / positive regulation of microtubule nucleation / cell projection membrane / XBP1(S) activates chaperone genes / dynein complex / attachment of mitotic spindle microtubules to kinetochore / COPI-independent Golgi-to-ER retrograde traffic / microtubule plus-end binding / non-motile cilium assembly / microtubule bundle formation / retrograde transport, endosome to Golgi / nuclear migration / protein localization to centrosome / motor behavior / microtubule organizing center / microtubule associated complex / neuromuscular process / negative regulation of microtubule polymerization / neuromuscular junction development / intercellular bridge / mitotic spindle pole / cytoplasmic microtubule / cell leading edge / establishment of mitotic spindle orientation / microtubule polymerization / regulation of microtubule polymerization or depolymerization / spindle assembly / spindle midzone / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / COPI-mediated anterograde transport / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / regulation of mitotic spindle organization / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / positive regulation of microtubule polymerization / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / Resolution of Sister Chromatid Cohesion / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / neuron projection maintenance / MHC class II antigen presentation / centriole / tubulin binding / AURKA Activation by TPX2 / ciliary basal body / RHO GTPases Activate Formins / tau protein binding / mitotic spindle / kinetochore / spindle pole / spindle / neuron cellular homeostasis / Separation of Sister Chromatids / The role of GTSE1 in G2/M progression after G2 checkpoint / microtubule cytoskeleton / Regulation of PLK1 Activity at G2/M Transition / protein localization / Signaling by ALK fusions and activated point mutants / cell migration / nuclear envelope / mitotic cell cycle / nervous system development / cell cortex / microtubule binding / microtubule / neuron projection / cadherin binding / cell division / axon / focal adhesion / centrosome / neuronal cell body / protein kinase binding / Golgi apparatus / RNA binding / identical protein binding / membrane / cytosol / cytoplasm Similarity search - Function
Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #1430 / Dynein associated protein / Dynein associated protein / CAP Gly-rich-like domain / EB1, C-terminal / Microtubule-associated protein RP/EB / EB1, C-terminal domain superfamily / EB1-C terminal (EB1-C) domain profile. / EB1-like C-terminal motif / CAP-Gly domain signature. ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #1430 / Dynein associated protein / Dynein associated protein / CAP Gly-rich-like domain / EB1, C-terminal / Microtubule-associated protein RP/EB / EB1, C-terminal domain superfamily / EB1-C terminal (EB1-C) domain profile. / EB1-like C-terminal motif / CAP-Gly domain signature. / CAP Gly-rich domain / CAP Gly-rich domain superfamily / CAP-Gly domain / CAP-Gly domain profile. / CAP_GLY / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / SH3 type barrels. / Roll / Up-down Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homology
A: Microtubule-associated protein RP/EB family member 1 C: Dynactin-1 B: Microtubule-associated protein RP/EB family member 1 D: Dynactin-1 hetero molecules
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