Entry Database : PDB / ID : 2h64 Structure visualization Downloads & linksTitle Crystal structure of a ternary ligand-receptor complex of BMP-2 ComponentsAcvr2b protein Bone morphogenetic protein 2 Bone morphogenetic protein receptor type IA DetailsKeywords Hormone/Growth Factor / TGF-beta superfamily / ligand-receptor complex / Hormone-Growth Factor COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
Signaling by Activin / neural plate mediolateral regionalization / paraxial mesoderm structural organization / positive regulation of cardiac ventricle development / fibrous ring of heart morphogenesis / positive regulation of transforming growth factor beta2 production / inhibin binding / Mullerian duct regression / Signaling by BMP / activin receptor activity, type II ... Signaling by Activin / neural plate mediolateral regionalization / paraxial mesoderm structural organization / positive regulation of cardiac ventricle development / fibrous ring of heart morphogenesis / positive regulation of transforming growth factor beta2 production / inhibin binding / Mullerian duct regression / Signaling by BMP / activin receptor activity, type II / cardiac atrium formation / cardiocyte differentiation / negative regulation of calcium-independent cell-cell adhesion / cardiac jelly development / heart formation / atrioventricular node cell development / negative regulation of aldosterone biosynthetic process / embryonic heart tube anterior/posterior pattern specification / atrioventricular canal morphogenesis / negative regulation of cortisol biosynthetic process / mesenchymal cell proliferation involved in ureteric bud development / lymphatic endothelial cell differentiation / mesendoderm development / negative regulation of steroid biosynthetic process / ameloblast differentiation / tricuspid valve morphogenesis / positive regulation of activin receptor signaling pathway / positive regulation of extracellular matrix constituent secretion / atrioventricular valve development / activin receptor activity / dorsal aorta morphogenesis / negative regulation of cardiac muscle cell differentiation / regulation of odontogenesis of dentin-containing tooth / endodermal-mesodermal cell signaling / central nervous system neuron differentiation / corticotropin hormone secreting cell differentiation / cardiac right ventricle morphogenesis / negative regulation of insulin-like growth factor receptor signaling pathway / thyroid-stimulating hormone-secreting cell differentiation / venous blood vessel development / mesenchyme development / pharyngeal arch artery morphogenesis / aortic valve development / telencephalon regionalization / positive regulation of odontogenesis / BMP binding / regulation of cardiac muscle cell proliferation / positive regulation of phosphatase activity / hindlimb morphogenesis / negative regulation of muscle cell differentiation / negative regulation of smooth muscle cell migration / positive regulation of cartilage development / proteoglycan metabolic process / heart induction / positive regulation of peroxisome proliferator activated receptor signaling pathway / lateral mesoderm development / regulation of lateral mesodermal cell fate specification / ventricular compact myocardium morphogenesis / pericardium development / pituitary gland development / lung vasculature development / lymphangiogenesis / mitral valve morphogenesis / BMP receptor complex / retina vasculature development in camera-type eye / BMP receptor activity / dorsal/ventral axis specification / co-receptor binding / regulation of cellular senescence / neural crest cell development / telencephalon development / embryonic foregut morphogenesis / cardiac epithelial to mesenchymal transition / mesenchymal cell differentiation / BMP receptor binding / transforming growth factor beta receptor activity, type I / ectoderm development / activin receptor complex / positive regulation of odontoblast differentiation / cardiac conduction system development / endocardial cushion formation / positive regulation of bone mineralization involved in bone maturation / phosphatase activator activity / Transcriptional regulation by RUNX2 / artery development / positive regulation of astrocyte differentiation / receptor protein serine/threonine kinase / pattern specification process / transmembrane receptor protein serine/threonine kinase activity / Signaling by BMP / activin binding / cellular response to BMP stimulus / cardiac muscle cell differentiation / outflow tract septum morphogenesis / activin receptor signaling pathway / cardiac muscle tissue morphogenesis / ventricular trabecula myocardium morphogenesis / kinase activator activity / positive regulation of ossification / astrocyte differentiation Similarity search - Function : / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif ... : / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Cystine-knot cytokine / Ribbon / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta Similarity search - Domain/homology Bone morphogenetic protein 2 / Activin receptor type-2B / Bone morphogenetic protein receptor type-1A / Activin receptor type-2B Similarity search - ComponentBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 1.92 Å DetailsAuthors Mueller, T.D. / Sebald, W. / Weber, D. CitationJournal : Bmc Struct.Biol. / Year : 2007Title : A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.Authors : Weber, D. / Kotzsch, A. / Nickel, J. / Harth, S. / Seher, A. / Mueller, U. / Sebald, W. / Mueller, T.D. History Deposition May 30, 2006 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 10, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Oct 20, 2021 Group : Database references / Category : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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