登録情報 | データベース: PDB / ID: 2h2g |
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タイトル | The Structural Basis of Sirtuin substrate affinity |
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要素 | - HISTONE H3 PEPTIDE
- NAD-dependent deacetylase
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キーワード | HYDROLASE / H3-K115AC / SIR2 / SIR2TM / SIRTUIN / SIRT1 / HISTONE H3 |
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機能・相同性 | 機能・相同性情報
sexual sporulation resulting in formation of a cellular spore / global genome nucleotide-excision repair / RNA polymerase I upstream activating factor complex / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Assembly of the ORC complex at the origin of replication / protein acetyllysine N-acetyltransferase / NAD-dependent histone deacetylase activity / replication fork protection complex ...sexual sporulation resulting in formation of a cellular spore / global genome nucleotide-excision repair / RNA polymerase I upstream activating factor complex / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Assembly of the ORC complex at the origin of replication / protein acetyllysine N-acetyltransferase / NAD-dependent histone deacetylase activity / replication fork protection complex / Oxidative Stress Induced Senescence / positive regulation of transcription by RNA polymerase I / RNA Polymerase I Promoter Escape / nucleolar large rRNA transcription by RNA polymerase I / Estrogen-dependent gene expression / rRNA transcription / NAD+ binding / CENP-A containing nucleosome / structural constituent of chromatin / nucleosome / chromatin organization / transferase activity / protein heterodimerization activity / regulation of DNA-templated transcription / DNA binding / zinc ion binding / nucleus / cytoplasm類似検索 - 分子機能 Sirtuin, class U / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily ...Sirtuin, class U / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-fold / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Histone H3 / NAD-dependent protein deacetylase類似検索 - 構成要素 |
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生物種 | ![](img/tx_bacteria.gif) Thermotoga maritima (バクテリア) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.63 Å |
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データ登録者 | Cosgrove, M.S. / Wolberger, C. |
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引用 | ジャーナル: Biochemistry / 年: 2006 タイトル: The structural basis of sirtuin substrate affinity 著者: Cosgrove, M.S. / Bever, K. / Avalos, J.L. / Muhammad, S. / Zhang, X. / Wolberger, C. |
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履歴 | 登録 | 2006年5月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年11月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2012年6月27日 | Group: Structure summary |
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改定 1.4 | 2019年7月24日 | Group: Data collection / Derived calculations / Refinement description カテゴリ: software / struct_conn Item: _software.name / _software.version / _struct_conn.pdbx_leaving_atom_flag |
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