登録情報 データベース : PDB / ID : 2fzs 構造の表示 ダウンロードとリンクタイトル Crystal structure of E. coli ClpP with a Peptide Chloromethyl Ketone Covalently Bound at the Active Site 要素ATP-dependent Clp protease proteolytic subunit 詳細 キーワード HYDROLASE / ATP-dependent ClpP protease / Z-Leu-Tyr Chloromethyl Ketone Inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
HslUV protease complex / endopeptidase Clp / endopeptidase Clp complex / positive regulation of programmed cell death / response to temperature stimulus / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / proteasomal protein catabolic process / serine-type peptidase activity / response to radiation ... HslUV protease complex / endopeptidase Clp / endopeptidase Clp complex / positive regulation of programmed cell death / response to temperature stimulus / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / proteasomal protein catabolic process / serine-type peptidase activity / response to radiation / ATPase binding / response to heat / serine-type endopeptidase activity / proteolysis / identical protein binding / membrane / cytosol 類似検索 - 分子機能 ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / 2-enoyl-CoA Hydratase; Chain A, domain 1 / 2-enoyl-CoA Hydratase; Chain A, domain 1 / ClpP/crotonase-like domain superfamily ... ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / 2-enoyl-CoA Hydratase; Chain A, domain 1 / 2-enoyl-CoA Hydratase; Chain A, domain 1 / ClpP/crotonase-like domain superfamily / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性 Chem-CMQ / TRIETHYLENE GLYCOL / ATP-dependent Clp protease proteolytic subunit 類似検索 - 構成要素生物種 Escherichia coli (大腸菌)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Szyk, A. / Maurizi, M.R. 引用ジャーナル : J.Struct.Biol. / 年 : 2006タイトル : Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.著者 : Szyk, A. / Maurizi, M.R. 履歴 登録 2006年2月10日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2006年5月23日 Provider : repository / タイプ : Initial release改定 1.1 2008年5月1日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Advisory / Version format compliance改定 1.3 2023年8月30日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
すべて表示 表示を減らす Remark 600 HETEROGEN THE BENZYLOXYCARBONYL-LEUCYLTYROSINE CHLOROMETHYL KETONE (Z-LEU-TYR-CMK) REACTS WITH CLPP ... HETEROGEN THE BENZYLOXYCARBONYL-LEUCYLTYROSINE CHLOROMETHYL KETONE (Z-LEU-TYR-CMK) REACTS WITH CLPP AND FORMS TWO COVALENT BONDS WITH SER97 AND HIS122 FROM ACTIVE SITE OF PROTEIN. THE HYDROXYL GROUP OF SER97 CREATE TETRAHEDRAL ADDUCT WITH THE KETONE CARBONYL CARBON OF THE INHIBITOR. THE NE2 IMIDAZOLE NITROGEN OF HIS122 IS COVALENTLY BOUND TO THE METHYLENE GROUP OF THE Z-LEU-TYR-CMK.