登録情報 | データベース: PDB / ID: 2fci |
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タイトル | Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase |
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要素 | - C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759
- Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350
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キーワード | HYDROLASE / SH2 domain / phosphopeptide / Syk kinase / PLCgamma / PLCC |
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機能・相同性 | 機能・相同性情報
calcium-dependent phospholipase C activity / phosphoinositide phospholipase C / phospholipid catabolic process / phosphatidylinositol metabolic process / phosphatidylinositol phospholipase C activity / COP9 signalosome / positive regulation of epithelial cell migration / phosphatidylinositol-mediated signaling / cellular response to epidermal growth factor stimulus / cellular response to vascular endothelial growth factor stimulus ...calcium-dependent phospholipase C activity / phosphoinositide phospholipase C / phospholipid catabolic process / phosphatidylinositol metabolic process / phosphatidylinositol phospholipase C activity / COP9 signalosome / positive regulation of epithelial cell migration / phosphatidylinositol-mediated signaling / cellular response to epidermal growth factor stimulus / cellular response to vascular endothelial growth factor stimulus / release of sequestered calcium ion into cytosol / ruffle / guanyl-nucleotide exchange factor activity / epidermal growth factor receptor signaling pathway / non-specific protein-tyrosine kinase / ruffle membrane / non-membrane spanning protein tyrosine kinase activity / lamellipodium / adaptive immune response / in utero embryonic development / intracellular signal transduction / calcium ion binding / ATP binding / plasma membrane / cytoplasm類似検索 - 分子機能 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain ...1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / Phosphatidylinositol-specific phospholipase X-box domain profile. / Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / SH2 domain / SHC Adaptor Protein / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / EF-Hand 1, calcium-binding site / Src homology 3 domains / EF-hand calcium-binding domain. / SH2 domain superfamily / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / EF-hand domain / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain pair / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / PH-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / Tyrosine-protein kinase類似検索 - 構成要素 |
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生物種 | Bos taurus (ウシ) |
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手法 | 溶液NMR |
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Model type details | minimized average |
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データ登録者 | Groesch, T.D. / Zhou, F. / Mattila, S. / Geahlen, R.L. / Post, C.B. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2006 タイトル: Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase 著者: Groesch, T.D. / Zhou, F. / Mattila, S. / Geahlen, R.L. / Post, C.B. |
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履歴 | 登録 | 2005年12月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年1月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2012年5月2日 | Group: Structure summary |
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改定 2.0 | 2023年11月15日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Database references / Derived calculations カテゴリ: atom_site / chem_comp_atom ...atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_validate_close_contact / struct_conn / struct_ref_seq_dif Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_validate_close_contact.auth_atom_id_1 / _pdbx_validate_close_contact.auth_atom_id_2 / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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