- PDB-2etx: Crystal Structure of MDC1 Tandem BRCT Domains -
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基本情報
登録情報
データベース: PDB / ID: 2etx
タイトル
Crystal Structure of MDC1 Tandem BRCT Domains
要素
Mediator of DNA damage checkpoint protein 1
キーワード
CELL CYCLE / TANDEM BRCT DOMAINS HISTONE GAMMA-H2AX
機能・相同性
機能・相同性情報
chromatin-protein adaptor activity / DNA replication checkpoint signaling / protein localization to site of double-strand break / mitotic intra-S DNA damage checkpoint signaling / positive regulation of transcription initiation by RNA polymerase II / SUMOylation of DNA damage response and repair proteins / histone reader activity / TP53 Regulates Transcription of DNA Repair Genes / Nonhomologous End-Joining (NHEJ) / G2/M DNA damage checkpoint ...chromatin-protein adaptor activity / DNA replication checkpoint signaling / protein localization to site of double-strand break / mitotic intra-S DNA damage checkpoint signaling / positive regulation of transcription initiation by RNA polymerase II / SUMOylation of DNA damage response and repair proteins / histone reader activity / TP53 Regulates Transcription of DNA Repair Genes / Nonhomologous End-Joining (NHEJ) / G2/M DNA damage checkpoint / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / chromosome / site of double-strand break / Processing of DNA double-strand break ends / nuclear body / DNA repair / focal adhesion / DNA damage response / nucleoplasm / nucleus 類似検索 - 分子機能
構造決定の手法: 多波長異常分散 / 解像度: 1.33→59.34 Å / Cor.coef. Fo:Fc: 0.945 / Cor.coef. Fo:Fc free: 0.932 / SU B: 0.826 / SU ML: 0.036 / 交差検証法: THROUGHOUT / ESU R: 0.062 / ESU R Free: 0.063 立体化学のターゲット値: MAXIMUM LIKELIHOOD WITH PHASES 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.22574
4300
5 %
RANDOM
Rwork
0.20158
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all
0.201
85639
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obs
0.20279
81339
98.95 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK