登録情報 | データベース: PDB / ID: 2dos |
---|
タイトル | Structural basis for the recognition of Lys48-linked polyubiquitin chain by the Josephin domain of ataxin-3, a putative deubiquitinating enzyme |
---|
要素 | Ataxin-3 |
---|
キーワード | HYDROLASE / Deubiquitinating enzyme |
---|
機能・相同性 | 機能・相同性情報
protein localization to cytosolic proteasome complex / regulation of cell-substrate adhesion / positive regulation of ERAD pathway / monoubiquitinated protein deubiquitination / intermediate filament cytoskeleton organization / protein K48-linked deubiquitination / nuclear inclusion body / positive regulation of ubiquitin-dependent protein catabolic process / protein K63-linked deubiquitination / cellular response to misfolded protein ...protein localization to cytosolic proteasome complex / regulation of cell-substrate adhesion / positive regulation of ERAD pathway / monoubiquitinated protein deubiquitination / intermediate filament cytoskeleton organization / protein K48-linked deubiquitination / nuclear inclusion body / positive regulation of ubiquitin-dependent protein catabolic process / protein K63-linked deubiquitination / cellular response to misfolded protein / K48-linked deubiquitinase activity / K63-linked deubiquitinase activity / protein quality control for misfolded or incompletely synthesized proteins / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / negative regulation of TORC1 signaling / cellular response to amino acid starvation / Josephin domain DUBs / mitochondrial membrane / nucleotide-excision repair / nuclear matrix / microtubule cytoskeleton organization / nervous system development / cellular response to heat / ATPase binding / actin cytoskeleton organization / ubiquitin-dependent protein catabolic process / chemical synaptic transmission / proteasome-mediated ubiquitin-dependent protein catabolic process / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / mitochondrial matrix / lysosomal membrane / synapse / ubiquitin protein ligase binding / nucleolus / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Cathepsin B; Chain A - #40 / Unstructured region C-term to UIM in Ataxin3 / Machado-Joseph disease protein / Josephin domain / Josephin / Josephin domain profile. / Josephin / Ubiquitin interaction motif / S15/NS1, RNA-binding / Ubiquitin-interacting motif. ...Cathepsin B; Chain A - #40 / Unstructured region C-term to UIM in Ataxin3 / Machado-Joseph disease protein / Josephin domain / Josephin / Josephin domain profile. / Josephin / Ubiquitin interaction motif / S15/NS1, RNA-binding / Ubiquitin-interacting motif. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. / Cathepsin B; Chain A / Helix Hairpins / Alpha-Beta Complex / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 溶液NMR / distance geometry, simulated annealing |
---|
データ登録者 | Sumiyoshi, A. |
---|
引用 | ジャーナル: Febs Lett. / 年: 2014 タイトル: Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity. 著者: Satoh, T. / Sumiyoshi, A. / Yagi-Utsumi, M. / Sakata, E. / Sasakawa, H. / Kurimoto, E. / Yamaguchi, Y. / Li, W. / Joazeiro, C.A. / Hirokawa, T. / Kato, K. |
---|
履歴 | 登録 | 2006年5月3日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2007年5月22日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年4月30日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.3 | 2014年12月3日 | Group: Database references |
---|
改定 1.4 | 2014年12月31日 | Group: Database references |
---|
改定 1.5 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
---|
|
---|