Entry | Database: PDB / ID: 2cn1 |
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Title | Crystal structure of Human Cytosolic 5'-Nucleotidase III (NT5C3) |
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Components | CYTOSOLIC 5'-NUCLEOTIDASE III |
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Keywords | HYDROLASE / NUCLEOTIDE-BINDING / UMPH1 / 5-PRIME / NUCLEOTIDASE |
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Function / homology | Function and homology information
tRNA 2'-phosphotransferase activity / pyrimidine nucleoside metabolic process / 7-methylguanosine nucleotidase / Pyrimidine catabolism / XMP 5'-nucleosidase activity / 5'-nucleotidase / 5'-nucleotidase activity / nucleotide metabolic process / defense response to virus / nuclear body ...tRNA 2'-phosphotransferase activity / pyrimidine nucleoside metabolic process / 7-methylguanosine nucleotidase / Pyrimidine catabolism / XMP 5'-nucleosidase activity / 5'-nucleotidase / 5'-nucleotidase activity / nucleotide metabolic process / defense response to virus / nuclear body / nucleotide binding / magnesium ion binding / endoplasmic reticulum / nucleoplasm / cytoplasm / cytosolSimilarity search - Function Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain / Pyrimidine 5'-nucleotidase, eukaryotic / Pyrimidine 5'-nucleotidase (UMPH-1) / HAD superfamily/HAD-like / HAD superfamily / HAD-like superfamily / DNA polymerase; domain 1 / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich ...Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain / Pyrimidine 5'-nucleotidase, eukaryotic / Pyrimidine 5'-nucleotidase (UMPH-1) / HAD superfamily/HAD-like / HAD superfamily / HAD-like superfamily / DNA polymerase; domain 1 / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.67 Å |
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Authors | Wallden, K. / Stenmark, P. / Arrowsmith, C. / Berglund, H. / Collins, R. / Edwards, A. / Ehn, M. / Flodin, S. / Flores, A. / Graslund, S. ...Wallden, K. / Stenmark, P. / Arrowsmith, C. / Berglund, H. / Collins, R. / Edwards, A. / Ehn, M. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Hallberg, B.M. / Holmberg Schiavone, L. / Hogbom, M. / Kotenyova, T. / Magnusdottir, A. / Nilsson-Ehle, P. / Nyman, T. / Ogg, D. / Persson, C. / Sagemark, J. / Sundstrom, M. / Thorsell, A.G. / Uppenberg, J. / Van Den Berg, S. / Weigelt, J. / Welin, M. / Nordlund, P. |
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Citation | Journal: J.Biol.Chem. / Year: 2007 Title: Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition. Authors: Wallden, K. / Stenmark, P. / Nyman, T. / Flodin, S. / Graslund, S. / Loppnau, P. / Bianchi, V. / Nordlund, P. |
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History | Deposition | May 17, 2006 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 12, 2006 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Dec 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description / Structure summary Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct.title |
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