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Open data
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Basic information
Entry | Database: PDB / ID: 2c2v | ||||||
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Title | Crystal structure of the CHIP-UBC13-UEV1a complex | ||||||
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![]() | CHAPERONE / HEAT-SHOCK PROTEIN COMPLEX / E3 LIGASE / UBIQUITINYLATION / TPR / HEAT-SHOCK PROTEIN | ||||||
Function / homology | ![]() positive regulation of chaperone-mediated protein complex assembly / Downregulation of TGF-beta receptor signaling / regulation of glucocorticoid metabolic process / Downregulation of ERBB2 signaling / : / UBC13-MMS2 complex / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / Regulation of PTEN stability and activity / Regulation of RUNX2 expression and activity ...positive regulation of chaperone-mediated protein complex assembly / Downregulation of TGF-beta receptor signaling / regulation of glucocorticoid metabolic process / Downregulation of ERBB2 signaling / : / UBC13-MMS2 complex / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / Regulation of PTEN stability and activity / Regulation of RUNX2 expression and activity / ubiquitin conjugating enzyme complex / positive regulation of ERAD pathway / ubiquitin-protein transferase activator activity / positive regulation of mitophagy / positive regulation of smooth muscle cell apoptotic process / positive regulation of protein K63-linked ubiquitination / DNA double-strand break processing / nuclear inclusion body / Antigen processing: Ubiquitination & Proteasome degradation / misfolded protein binding / protein folding chaperone complex / postreplication repair / cellular response to misfolded protein / positive regulation of ubiquitin-protein transferase activity / positive regulation of double-strand break repair / positive regulation of intracellular signal transduction / ubiquitin-ubiquitin ligase activity / chaperone-mediated autophagy / E2 ubiquitin-conjugating enzyme / TPR domain binding / protein quality control for misfolded or incompletely synthesized proteins / protein monoubiquitination / negative regulation of smooth muscle cell apoptotic process / R-SMAD binding / ubiquitin conjugating enzyme activity / protein K63-linked ubiquitination / positive regulation of proteolysis / antiviral innate immune response / protein maturation / protein autoubiquitination / regulation of DNA repair / ERAD pathway / ubiquitin ligase complex / endoplasmic reticulum unfolded protein response / negative regulation of TORC1 signaling / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / heat shock protein binding / Hsp70 protein binding / positive regulation of DNA repair / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / TICAM1, RIP1-mediated IKK complex recruitment / IKK complex recruitment mediated by RIP1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / negative regulation of protein binding / ubiquitin binding / positive regulation of protein ubiquitination / activated TAK1 mediates p38 MAPK activation / response to ischemia / G protein-coupled receptor binding / Nonhomologous End-Joining (NHEJ) / negative regulation of transforming growth factor beta receptor signaling pathway / double-strand break repair via homologous recombination / TAK1-dependent IKK and NF-kappa-B activation / Hsp90 protein binding / RING-type E3 ubiquitin transferase / NOD1/2 Signaling Pathway / G2/M DNA damage checkpoint / ISG15 antiviral mechanism / CLEC7A (Dectin-1) signaling / kinase binding / Formation of Incision Complex in GG-NER / Z disc / FCERI mediated NF-kB activation / Aggrephagy / Interleukin-1 signaling / protein polyubiquitination / ubiquitin-protein transferase activity / MAPK cascade / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Downstream TCR signaling / protein folding / E3 ubiquitin ligases ubiquitinate target proteins / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / protein-macromolecule adaptor activity / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / cellular response to heat / Processing of DNA double-strand break ends / protein-folding chaperone binding / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / positive regulation of canonical NF-kappaB signal transduction / cell differentiation / protein stabilization / protein ubiquitination / DNA repair Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Zhang, M. / Roe, S.M. / Pearl, L.H. | ||||||
![]() | ![]() Title: Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Authors: Zhang, M. / Windheim, M. / Roe, S.M. / Peggie, M. / Cohen, P. / Prodromou, C. / Pearl, L.H. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 294 KB | Display | ![]() |
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PDB format | ![]() | 216.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 540.7 KB | Display | ![]() |
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Full document | ![]() | 908.3 KB | Display | |
Data in XML | ![]() | 95.1 KB | Display | |
Data in CIF | ![]() | 121.1 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2c2lC ![]() 1jatS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Refine code: 4
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