登録情報 データベース : PDB / ID : 2brc 構造の表示 ダウンロードとリンクタイトル Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90. 要素ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 詳細 キーワード CHAPERONE / ATP-BINDING / HEAT SHOCK / INHIBITOR / MULTIGENE FAMILY / CHAPERONE-COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
The NLRP3 inflammasome / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / eNOS activation / Extra-nuclear estrogen signaling / VEGFR2 mediated vascular permeability / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / HSF1-dependent transactivation / HSF1 activation / response to oxygen levels / protein targeting to mitochondrion ... The NLRP3 inflammasome / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / eNOS activation / Extra-nuclear estrogen signaling / VEGFR2 mediated vascular permeability / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / HSF1-dependent transactivation / HSF1 activation / response to oxygen levels / protein targeting to mitochondrion / box C/D snoRNP assembly / regulation of telomere maintenance / response to osmotic stress / 'de novo' protein folding / protein maturation / proteasome assembly / Neutrophil degranulation / positive regulation of telomere maintenance via telomerase / ATP-dependent protein folding chaperone / disordered domain specific binding / unfolded protein binding / protein folding / cellular response to heat / protein refolding / protein stabilization / perinuclear region of cytoplasm / ATP hydrolysis activity / protein-containing complex / ATP binding / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ... Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Chem-CT5 / ATP-dependent molecular chaperone HSP82 類似検索 - 構成要素生物種 SACCHAROMYCES CEREVISIAE (パン酵母)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.6 Å 詳細データ登録者 Roe, S.M. / Pearl, L.H. / Prodromou, C. 引用ジャーナル : Bioorg. Med. Chem. Lett. / 年 : 2005タイトル : The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.著者 : Cheung, K.M. / Matthews, T.P. / James, K. / Rowlands, M.G. / Boxall, K.J. / Sharp, S.Y. / Maloney, A. / Roe, S.M. / Prodromou, C. / Pearl, L.H. / Aherne, G.W. / McDonald, E. / Workman, P. 履歴 登録 2005年5月4日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2005年9月29日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2018年2月28日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_abbrev / _citation.page_last ... _citation.journal_abbrev / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name 改定 1.4 2023年12月13日 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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