登録情報 | データベース: PDB / ID: 2a5t |
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タイトル | Crystal Structure Of The NR1/NR2A ligand-binding cores complex |
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要素 | - N-methyl-D-aspartate receptor NMDAR1-4a subunit
- N-methyl-D-aspartate receptor NMDAR2A subunit
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キーワード | METAL TRANSPORT / MEMBRANE PROTEIN / Protein-ligand complex |
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機能・相同性 | 機能・相同性情報
neurotransmitter receptor transport, plasma membrane to endosome / regulation of response to alcohol / response to ammonium ion / receptor recycling / directional locomotion / pons maturation / response to environmental enrichment / positive regulation of Schwann cell migration / regulation of cell communication / EPHB-mediated forward signaling ...neurotransmitter receptor transport, plasma membrane to endosome / regulation of response to alcohol / response to ammonium ion / receptor recycling / directional locomotion / pons maturation / response to environmental enrichment / positive regulation of Schwann cell migration / regulation of cell communication / EPHB-mediated forward signaling / auditory behavior / Assembly and cell surface presentation of NMDA receptors / response to hydrogen sulfide / olfactory learning / conditioned taste aversion / dendritic branch / regulation of respiratory gaseous exchange / serotonin metabolic process / response to other organism / protein localization to postsynaptic membrane / regulation of ARF protein signal transduction / cellular response to magnesium ion / transmitter-gated monoatomic ion channel activity / positive regulation of inhibitory postsynaptic potential / suckling behavior / response to methylmercury / sleep / response to glycine / propylene metabolic process / response to manganese ion / response to carbohydrate / dendritic spine organization / locomotion / regulation of NMDA receptor activity / cellular response to dsRNA / cellular response to lipid / regulation of monoatomic cation transmembrane transport / NMDA glutamate receptor activity / Synaptic adhesion-like molecules / RAF/MAP kinase cascade / voltage-gated monoatomic cation channel activity / response to glycoside / NMDA selective glutamate receptor complex / neurotransmitter receptor complex / ligand-gated sodium channel activity / glutamate binding / response to morphine / glutamate receptor signaling pathway / calcium ion transmembrane import into cytosol / regulation of axonogenesis / neuromuscular process / regulation of dendrite morphogenesis / protein heterotetramerization / male mating behavior / glycine binding / regulation of synapse assembly / spinal cord development / response to amine / parallel fiber to Purkinje cell synapse / cellular response to zinc ion / startle response / positive regulation of reactive oxygen species biosynthetic process / monoatomic cation transmembrane transport / dopamine metabolic process / response to lithium ion / positive regulation of calcium ion transport into cytosol / modulation of excitatory postsynaptic potential / response to light stimulus / regulation of postsynaptic membrane potential / regulation of neuron apoptotic process / action potential / associative learning / cellular response to glycine / monoatomic cation transport / conditioned place preference / excitatory synapse / social behavior / positive regulation of dendritic spine maintenance / regulation of neuronal synaptic plasticity / monoatomic ion channel complex / positive regulation of protein targeting to membrane / positive regulation of excitatory postsynaptic potential / glutamate receptor binding / Unblocking of NMDA receptors, glutamate binding and activation / long-term memory / positive regulation of synaptic transmission, glutamatergic / synaptic cleft / multicellular organismal response to stress / neuron development / prepulse inhibition / postsynaptic density, intracellular component / phosphatase binding / monoatomic cation channel activity / calcium ion homeostasis / response to fungicide / glutamate-gated receptor activity / cell adhesion molecule binding / glutamate-gated calcium ion channel activity / cellular response to manganese ion / presynaptic active zone membrane類似検索 - 分子機能 Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ligand-gated ion channel / : ...Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ligand-gated ion channel / : / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like II / Periplasmic binding protein-like I / D-Maltodextrin-Binding Protein; domain 2 / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 GLUTAMIC ACID / GLYCINE / : / : / Glutamate receptor ionotropic, NMDA 1 / Glutamate receptor ionotropic, NMDA 2A類似検索 - 構成要素 |
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生物種 |  Rattus norvegicus (ドブネズミ)
 Canis lupus familiaris (イヌ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Furukawa, H. / Singh, S.K. / Mancusso, R. / Gouaux, E. |
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引用 | ジャーナル: Nature / 年: 2005 タイトル: Subunit arrangement and function in NMDA receptors 著者: Furukawa, H. / Singh, S.K. / Mancusso, R. / Gouaux, E. |
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履歴 | 登録 | 2005年6月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2005年11月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2017年7月26日 | Group: Refinement description / Source and taxonomy / カテゴリ: entity_src_gen / software |
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改定 1.4 | 2024年11月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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