登録情報 データベース : PDB / ID : 1z8g 構造の表示 ダウンロードとリンクタイトル Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate. 要素ACE-LYS-GLN-LEU-ARG-Chloromethylketone Serine protease hepsin 詳細キーワード HYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEASE HEPSIN / PROTEASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
hepsin / pilomotor reflex / Signaling by MST1 / positive regulation of thyroid hormone generation / cochlea morphogenesis / serine-type exopeptidase activity / positive regulation of plasminogen activation / basement membrane disassembly / detection of mechanical stimulus involved in sensory perception of sound / MET Receptor Activation ... hepsin / pilomotor reflex / Signaling by MST1 / positive regulation of thyroid hormone generation / cochlea morphogenesis / serine-type exopeptidase activity / positive regulation of plasminogen activation / basement membrane disassembly / detection of mechanical stimulus involved in sensory perception of sound / MET Receptor Activation / response to thyroid hormone / negative regulation of epithelial to mesenchymal transition / positive regulation of hepatocyte proliferation / positive regulation by host of viral transcription / potassium ion transmembrane transport / serine-type peptidase activity / negative regulation of epithelial cell proliferation / cell-cell junction / peptidase activity / regulation of cell shape / positive regulation of cell growth / apical plasma membrane / serine-type endopeptidase activity / neuronal cell body / endoplasmic reticulum membrane / positive regulation of gene expression / negative regulation of apoptotic process / cell surface / proteolysis / extracellular exosome / membrane / plasma membrane 類似検索 - 分子機能 Hepsin, SRCR domain / Hepsin, SRCR domain / Mac-2 Binding Protein / SRCR-like domain / SRCR-like domain / SRCR-like domain superfamily / Scavenger receptor Cys-rich / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family ... Hepsin, SRCR domain / Hepsin, SRCR domain / Mac-2 Binding Protein / SRCR-like domain / SRCR-like domain / SRCR-like domain superfamily / Scavenger receptor Cys-rich / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Roll / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 N-acetyl-6-ammonio-L-norleucyl-L-glutaminyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl)butyl]-L-leucinamide / Serine protease hepsin 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.55 Å 詳細データ登録者 Herter, S. / Piper, D.E. / Aaron, W. / Gabriele, T. / Cutler, G. / Cao, P. / Bhatt, A.S. / Choe, Y. / Craik, C.S. / Walker, N. ...Herter, S. / Piper, D.E. / Aaron, W. / Gabriele, T. / Cutler, G. / Cao, P. / Bhatt, A.S. / Choe, Y. / Craik, C.S. / Walker, N. / Meininger, D. / Hoey, T. / Austin, R.J. 引用ジャーナル : Biochem.J. / 年 : 2005タイトル : Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers著者 : Herter, S. / Piper, D.E. / Aaron, W. / Gabriele, T. / Cutler, G. / Cao, P. / Bhatt, A.S. / Choe, Y. / Craik, C.S. / Walker, N. / Meininger, D. / Hoey, T. / Austin, R.J. 履歴 登録 2005年3月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2005年5月3日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance 改定 1.3 2012年12月12日 Group : Other改定 1.4 2021年10月20日 Group : Database references / Derived calculations / カテゴリ : database_2 / struct_conn / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details 改定 1.5 2023年8月23日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
すべて表示 表示を減らす Remark 999 SEQUENCE RESIDUES 160-162 ARE DISORDERED. THIS PEPTIDE BOND CLEAVAGE OCCURS DURING THE ACTIVATION ... SEQUENCE RESIDUES 160-162 ARE DISORDERED. THIS PEPTIDE BOND CLEAVAGE OCCURS DURING THE ACTIVATION OF THE PROTEASE.