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TitleHepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Journal, issue, pagesBiochem. J., Vol. 390, Page 125-136, Year 2005
Publish dateMar 30, 2005 (structure data deposition date)
AuthorsHerter, S. / Piper, D.E. / Aaron, W. / Gabriele, T. / Cutler, G. / Cao, P. / Bhatt, A.S. / Choe, Y. / Craik, C.S. / Walker, N. ...Herter, S. / Piper, D.E. / Aaron, W. / Gabriele, T. / Cutler, G. / Cao, P. / Bhatt, A.S. / Choe, Y. / Craik, C.S. / Walker, N. / Meininger, D. / Hoey, T. / Austin, R.J.
External linksBiochem. J. / PubMed:15839837
MethodsX-ray diffraction
Resolution1.55 Å
Structure data

PDB-1z8g:
Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEASE HEPSIN / PROTEASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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