Entry Database : PDB / ID : 1ywo Structure visualization Downloads & linksTitle Phospholipase Cgamma1 SH3 in complex with a SLP-76 motif Components1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 Lymphocyte cytosolic protein 2 DetailsKeywords HYDROLASE / SIGNALING PROTEIN / SH3 / Phospholipase C-gamma1 / SLP-76 / SH2 domain-containing leukocyte phosphoprotein of 76 kDFunction / homology Function and homology informationFunction Domain/homology Component
TCR signalosome / PECAM1 interactions / EGFR interacts with phospholipase C-gamma / Activated NTRK2 signals through PLCG1 / Activated NTRK3 signals through PLCG1 / phosphatidylinositol catabolic process / Phospholipase C-mediated cascade: FGFR1 / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR4 / FCERI mediated Ca+2 mobilization ... TCR signalosome / PECAM1 interactions / EGFR interacts with phospholipase C-gamma / Activated NTRK2 signals through PLCG1 / Activated NTRK3 signals through PLCG1 / phosphatidylinositol catabolic process / Phospholipase C-mediated cascade: FGFR1 / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR4 / FCERI mediated Ca+2 mobilization / ISG15 antiviral mechanism / Generation of second messenger molecules / Phospholipase C-mediated cascade; FGFR2 / Downstream signal transduction / Signaling by ALK / Role of phospholipids in phagocytosis / inositol trisphosphate biosynthetic process / DAP12 signaling / VEGFR2 mediated cell proliferation / calcium-dependent phospholipase C activity / Synthesis of IP3 and IP4 in the cytosol / RET signaling / inositol trisphosphate metabolic process / response to curcumin / mast cell activation / phosphoinositide phospholipase C / FCERI mediated MAPK activation / response to gravity / phosphatidylinositol metabolic process / phosphatidylinositol phospholipase C activity / COP9 signalosome / phospholipase C activity / neurotrophin TRKA receptor binding / positive regulation of endothelial cell apoptotic process / phosphatidylinositol-mediated signaling / positive regulation of vascular endothelial cell proliferation / clathrin-coated vesicle / positive regulation of epithelial cell migration / plasma membrane raft / Generation of second messenger molecules / glutamate receptor binding / positive regulation of blood vessel endothelial cell migration / positive regulation of protein kinase activity / release of sequestered calcium ion into cytosol / cellular response to epidermal growth factor stimulus / ruffle / GPVI-mediated activation cascade / response to organonitrogen compound / FCERI mediated Ca+2 mobilization / guanyl-nucleotide exchange factor activity / positive regulation of release of sequestered calcium ion into cytosol / cell projection / calcium-mediated signaling / FCERI mediated MAPK activation / phosphoprotein binding / modulation of chemical synaptic transmission / Schaffer collateral - CA1 synapse / response to hydrogen peroxide / insulin receptor binding / epidermal growth factor receptor signaling pathway / receptor tyrosine kinase binding / ruffle membrane / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of angiogenesis / calcium ion transport / cell-cell junction / cell migration / DAP12 signaling / lamellipodium / T cell receptor signaling pathway / in utero embryonic development / intracellular signal transduction / immune response / glutamatergic synapse / calcium ion binding / protein kinase binding / plasma membrane / cytosol / cytoplasm Similarity search - Function 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase X-box domain profile. ... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase X-box domain profile. / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / SAM domain (Sterile alpha motif) / SH3 Domains / Sterile alpha motif. / Sterile alpha motif domain / PH domain / Sterile alpha motif/pointed domain superfamily / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH3 type barrels. / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / SH2 domain superfamily / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain / EF-hand domain pair / PH-like domain superfamily / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.81 Å DetailsAuthors Deng, L. / Velikovsky, C.A. / Swaminathan, C.P. / Cho, S. / Mariuzza, R.A. CitationJournal : J.Mol.Biol. / Year : 2005Title : Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cgamma1Authors : Deng, L. / Velikovsky, C.A. / Swaminathan, C.P. / Cho, S. / Mariuzza, R.A. History Deposition Feb 18, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 16, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.3 Oct 20, 2021 Group : Database references / Category : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.detailsRevision 1.4 Feb 14, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
Show all Show less