- PDB-1yn7: Crystal structure of a mouse MHC class I protein, H2-Db, in compl... -
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基本情報
登録情報
データベース: PDB / ID: 1yn7
タイトル
Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a mutated peptide (R7A) of the influenza A acid polymerase
要素
10-mer peptide from RNA-directed RNA polymerase subunit P2
Beta-2-microglobulinΒ2-ミクログロブリン
H-2 class I histocompatibility antigen, D-B alpha chain
キーワード
IMMUNE SYSTEM (免疫系) / MHC class 1 / H2-Db / influenza A (A型インフルエンザウイルス) / peptide of acid polymerase
機能・相同性
機能・相同性情報
Endosomal/Vacuolar pathway / DAP12 interactions / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / ER-Phagosome pathway / DAP12 signaling / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / regulation of membrane depolarization / キャップスナッチング / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent ...Endosomal/Vacuolar pathway / DAP12 interactions / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / ER-Phagosome pathway / DAP12 signaling / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / regulation of membrane depolarization / キャップスナッチング / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent / cellular defense response / beta-2-microglobulin binding / Neutrophil degranulation / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / lumenal side of endoplasmic reticulum membrane / peptide binding / cellular response to iron(III) ion / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / negative regulation of forebrain neuron differentiation / regulation of erythrocyte differentiation / peptide antigen assembly with MHC class I protein complex / regulation of iron ion transport / response to molecule of bacterial origin / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / cellular response to iron ion / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / negative regulation of neurogenesis / peptide antigen assembly with MHC class II protein complex / positive regulation of receptor-mediated endocytosis / MHC class II protein complex / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / phagocytic vesicle membrane / peptide antigen binding / positive regulation of cellular senescence / antigen processing and presentation of exogenous peptide antigen via MHC class II / negative regulation of epithelial cell proliferation / positive regulation of immune response / sensory perception of smell / positive regulation of T cell activation / antimicrobial humoral immune response mediated by antimicrobial peptide / negative regulation of neuron projection development / MHC class II protein complex binding / late endosome membrane / iron ion transport / T cell differentiation in thymus / protein refolding / antibacterial humoral response / endonuclease activity / protein homotetramerization / intracellular iron ion homeostasis / cellular response to lipopolysaccharide / host cell cytoplasm / amyloid fibril formation / defense response to Gram-negative bacterium / 加水分解酵素; エステル加水分解酵素 / learning or memory / defense response to Gram-positive bacterium / 免疫応答 / lysosomal membrane / external side of plasma membrane / viral RNA genome replication / signaling receptor binding / 自然免疫系 / DNA-templated transcription / host cell nucleus / protein-containing complex binding / structural molecule activity / ゴルジ体 / protein homodimerization activity / extracellular space / RNA binding / identical protein binding / metal ion binding / 細胞膜 / 細胞質基質 類似検索 - 分子機能
Polymerase acidic protein / Influenza RNA-dependent RNA polymerase subunit PA / Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain / Influenza RNA-dependent RNA polymerase subunit PA / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I-like antigen recognition-like / Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 ...Polymerase acidic protein / Influenza RNA-dependent RNA polymerase subunit PA / Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain / Influenza RNA-dependent RNA polymerase subunit PA / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I-like antigen recognition-like / Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Β2-ミクログロブリン / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / 抗体 / Immunoglobulin-like fold / Immunoglobulin-like / サンドイッチ / 2-Layer Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性
Β2-ミクログロブリン / H-2 class I histocompatibility antigen, D-B alpha chain / Polymerase acidic protein 類似検索 - 構成要素
10-merpeptidefromRNA-directedRNApolymerasesubunitP2 / Polymerase acidic protein / PA
分子量: 1100.179 Da / 分子数: 1 / Mutation: R7A / 由来タイプ: 合成 詳細: Synthetic peptide with similar sequence as influenza A acid polymerase fragment 参照: UniProt: P13175, RNA依存性RNAポリメラーゼ