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- PDB-1xyk: NMR Structure of the canine prion protein -

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Database: PDB / ID: 1xyk
TitleNMR Structure of the canine prion protein
Descriptorprion protein
KeywordsUNKNOWN FUNCTION / PrP / prion / Prnp / cPrP
Specimen sourceCanis lupus familiaris / mammal / dog /
MethodSolution NMR (Torsion angle dynamics)
AuthorsLysek, D.A. / Schorn, C. / Esteve-Moya, V. / Herrmann, T. / Wuthrich, K.
CitationProc.Natl.Acad.Sci.USA, 2005, 102, 640-645

Proc.Natl.Acad.Sci.USA, 2005, 102, 640-645 Yorodumi Papers
Prion protein NMR structures of cats, dogs, pigs, and sheep
Lysek, D.A. / Schorn, C. / Nivon, L.G. / Esteve-Moya, V. / Christen, B. / Calzolai, L. / von Schroetter, C. / Fiorito, F. / Herrmann, T. / Guntert, P. / Wuthrich, K.

Validation Report
SummaryFull reportAbout validation report
DateDeposition: Nov 10, 2004 / Release: Jan 4, 2005
RevisionDateData content typeGroupProviderType
1.0Jan 4, 2005Structure modelrepositoryInitial release
1.1Apr 30, 2008Structure modelVersion format compliance
1.2Jul 13, 2011Structure modelVersion format compliance

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Deposited unit
A: prion protein

Theoretical massNumber of molelcules
Total (without water)13,0851
NMR ensembles
Number of conformers (submitted / calculated)20 / 100target function
RepresentativeModel #1fewest violations


#1: Polypeptide(L)prion protein

Mass: 13084.538 Da / Num. of mol.: 1 / Fragment: cPrP C-TERMINAL DOMAIN / Source: (gene. exp.) Canis lupus familiaris / mammal / / References: UniProt: O46501

Cellular component

Molecular function

Biological process

Experimental details


ExperimentMethod: SOLUTION NMR
NMR experiment
Conditions IDExperiment IDSolution IDType
NMR detailsText: This structure was determined using standard 3D techniques

Sample preparation

NMR sample detailsContents: 1mM cPrP U-15N, 13C; 10mM acetate / Solvent system: 90% H2O/10% D2O
NMR experiment sample conditionsIonic strength: 10 / pH: 4.5 / Pressure: ambient / Temperature: 293 kelvins / Temperature units: K

NMR measurement

RadiationDiffraction protocol: SINGLE WAVELENGTH / Monochromatic or laue m l: M
Radiation wavelengthRelative weight: 1
NMR spectrometerManufacturer: Bruker / Model: DRX / Field strength: 750


NMR software
DYANA6.2Gntertstructure solution
NMR refineMethod: torsion angle dynamics / Software ordinal: 1
NMR representativeSelection criteria: fewest violations
NMR ensembleConformer selection criteria: target function / Conformers calculated total number: 100 / Conformers submitted total number: 20

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