Entry Database : PDB / ID : 1w1f Structure visualization Downloads & linksTitle SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE ComponentsTYROSINE-PROTEIN KINASE LYN Details Keywords SH3-DOMAIN / SH3 DOMAIN / TYROSINE KINASE / SIGNAL TRANSDUCTION / LYNFunction / homology Function and homology informationFunction Domain/homology Component
C-X-C chemokine receptor CXCR4 signaling pathway / regulation of monocyte chemotaxis / negative regulation of intracellular signal transduction / response to sterol depletion / regulation of mast cell activation / negative regulation of myeloid leukocyte differentiation / eosinophil differentiation / Fc receptor mediated stimulatory signaling pathway / positive regulation of Fc receptor mediated stimulatory signaling pathway / positive regulation of dendritic cell apoptotic process ... C-X-C chemokine receptor CXCR4 signaling pathway / regulation of monocyte chemotaxis / negative regulation of intracellular signal transduction / response to sterol depletion / regulation of mast cell activation / negative regulation of myeloid leukocyte differentiation / eosinophil differentiation / Fc receptor mediated stimulatory signaling pathway / positive regulation of Fc receptor mediated stimulatory signaling pathway / positive regulation of dendritic cell apoptotic process / positive regulation of oligodendrocyte progenitor proliferation / Fc receptor mediated inhibitory signaling pathway / regulation of B cell receptor signaling pathway / tolerance induction to self antigen / negative regulation of toll-like receptor 2 signaling pathway / integrin alpha2-beta1 complex / immune response-regulating cell surface receptor signaling pathway / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / positive regulation of mast cell proliferation / negative regulation of mast cell proliferation / glycosphingolipid binding / phosphorylation-dependent protein binding / negative regulation of toll-like receptor 4 signaling pathway / regulation of mast cell degranulation / platelet degranulation / dendritic cell differentiation / regulation of platelet aggregation / : / regulation of B cell apoptotic process / oligodendrocyte development / phosphatidylinositol 3-kinase activator activity / Signaling by Erythropoietin / histamine secretion by mast cell / Erythropoietin activates STAT5 / interleukin-5-mediated signaling pathway / Erythropoietin activates Phospholipase C gamma (PLCG) / Platelet Adhesion to exposed collagen / CD28 co-stimulation / negative regulation of immune response / regulation of release of sequestered calcium ion into cytosol / CD22 mediated BCR regulation / gamma-tubulin binding / platelet-derived growth factor receptor binding / response to carbohydrate / Fc epsilon receptor (FCERI) signaling / EPH-Ephrin signaling / toll-like receptor 4 signaling pathway / Regulation of KIT signaling / postsynaptic specialization, intracellular component / CTLA4 inhibitory signaling / leukocyte migration / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Fc-gamma receptor signaling pathway involved in phagocytosis / EPHA-mediated growth cone collapse / Dectin-2 family / negative regulation of B cell proliferation / mitochondrial crista / stimulatory C-type lectin receptor signaling pathway / PECAM1 interactions / Fc-epsilon receptor signaling pathway / regulation of cell adhesion mediated by integrin / B cell homeostasis / FCGR activation / EPH-ephrin mediated repulsion of cells / response to axon injury / ephrin receptor signaling pathway / response to amino acid / Role of LAT2/NTAL/LAB on calcium mobilization / growth hormone receptor signaling pathway via JAK-STAT / hematopoietic progenitor cell differentiation / Erythropoietin activates RAS / cellular response to retinoic acid / Growth hormone receptor signaling / Signaling by CSF3 (G-CSF) / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of glial cell proliferation / lipopolysaccharide-mediated signaling pathway / extrinsic component of cytoplasmic side of plasma membrane / negative regulation of inflammatory response to antigenic stimulus / GPVI-mediated activation cascade / cell surface receptor protein tyrosine kinase signaling pathway / regulation of cytokine production / T cell costimulation / EPHB-mediated forward signaling / ephrin receptor binding / CD209 (DC-SIGN) signaling / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / erythrocyte differentiation / regulation of ERK1 and ERK2 cascade / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / negative regulation of protein phosphorylation / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / response to hormone / negative regulation of MAP kinase activity / DNA damage checkpoint signaling / Regulation of signaling by CBL / Cell surface interactions at the vascular wall / phosphoprotein binding / FCERI mediated MAPK activation Similarity search - Function Tyrosine-protein kinase Lyn, SH3 domain / Tyrosine-protein kinase Lyn, SH2 domain / SH3 Domains / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH3 type barrels. / SH2 domain / Src homology 3 domains ... Tyrosine-protein kinase Lyn, SH3 domain / Tyrosine-protein kinase Lyn, SH2 domain / SH3 Domains / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH3 type barrels. / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method SOLUTION NMR / X-PLOR DetailsAuthors Bauer, F. / Schweimer, K. / Hoffmann, S. / Roesch, P. / Sticht, H. CitationJournal : Protein Sci. / Year : 2005Title : Structural Characterization of Lyn-SH3 Domain in Complex with a Herpesviral Protein Reveals an Extended Recognition Motif that Enhances Binding Affinity.Authors : Bauer, F. / Schweimer, K. / Meiselbach, H. / Hoffmann, S. / Roesch, P. / Sticht, H. History Deposition Jun 17, 2004 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 6, 2005 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jan 15, 2020 Group : Data collection / Other / Category : pdbx_database_status / pdbx_nmr_softwareItem : _pdbx_database_status.status_code_cs / _pdbx_nmr_software.nameRevision 1.4 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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