Crystal structure of Ubiquitin carboxyl-terminal hydrolase 6 (yfr010w) from Saccharomyces cerevisiae at 1.74 A resolution
Components
Ubiquitin carboxyl-terminal hydrolase 6
Keywords
HYDROLASE / yfr010w / UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 6 / STRUCTURAL GENOMICS / JCSG / PSI / Protein Structure Initiative / Joint Center for Structural Genomics
Function / homology
Function and homology information
mitochondria-associated ubiquitin-dependent protein catabolic process / negative regulation of proteasomal protein catabolic process / regulation of proteasomal ubiquitin-dependent protein catabolic process / proteasome regulatory particle / proteasome binding / protein deubiquitination / Ub-specific processing proteases / regulation of proteasomal protein catabolic process / proteasome complex / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity Similarity search - Function
SEQUENCE MASS SPECTROMETER DATA AND SEQUENCING THE CONSTRUCT CONFIRMED THAT THE EXPRESSED PROTEIN ...SEQUENCE MASS SPECTROMETER DATA AND SEQUENCING THE CONSTRUCT CONFIRMED THAT THE EXPRESSED PROTEIN COMPRISED AN N-TERMINAL PURIFICATION TAG [MGSDKIHHHHHH] FOLLOWED BY RESIDUES 97-499 OF THE PREDICTED YFR010W GENE PRODUCT. CLONING ARTIFACT: THE DENSITY FOR RESIDUE 182 FROM EACH MONOMER SUGGESTED THAT THIS RESIDUE WAS AN VALINE AND NOT AN ISOLUCINE. SEQUENCING OF THE CONSTRUCT CONFIRMED THAT RESIDUE 182 IS VALINE IN THE EXPRESSED PROTEIN.
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