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- PDB-1ula: APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIG... -
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Basic information
Entry | Database: PDB / ID: 1ula | |||||||||
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Title | APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS | |||||||||
![]() | PURINE NUCLEOSIDE PHOSPHORYLASE![]() | |||||||||
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Function / homology | ![]() nicotinamide riboside catabolic process / Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine / purine-containing compound salvage / deoxyinosine catabolic process / purine nucleobase binding / inosine catabolic process / deoxyadenosine catabolic process / dAMP catabolic process / nucleotide biosynthetic process / urate biosynthetic process ...nicotinamide riboside catabolic process / Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine / purine-containing compound salvage / deoxyinosine catabolic process / purine nucleobase binding / inosine catabolic process / deoxyadenosine catabolic process / dAMP catabolic process / nucleotide biosynthetic process / urate biosynthetic process / Ribavirin ADME / IMP catabolic process / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | |||||||||
Biological species | ![]() ![]() | |||||||||
Method | ![]() | |||||||||
![]() | Ealick, S.E. / Rule, S.A. / Carter, D.C. / Greenhough, T.J. / Babu, Y.S. / Cook, W.J. / Habash, J. / Helliwell, J.R. / Stoeckler, J.D. / Parksjunior, R.E. ...Ealick, S.E. / Rule, S.A. / Carter, D.C. / Greenhough, T.J. / Babu, Y.S. / Cook, W.J. / Habash, J. / Helliwell, J.R. / Stoeckler, J.D. / Parksjunior, R.E. / Chen, S.-F. / Bugg, C.E. | |||||||||
![]() | ![]() Title: Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors. Authors: Ealick, S.E. / Babu, Y.S. / Bugg, C.E. / Erion, M.D. / Guida, W.C. / Montgomery, J.A. / Secrist 3rd., J.A. #1: ![]() Title: Three-Dimensional Structure of Human Erythrocytic Purine Nucleoside Phosphorylase at 3.2 Angstroms Resolution Authors: Ealick, S.E. / Rule, S.A. / Carter, D.C. / Greenhough, T.J. / Babu, Y.S. / Cook, W.J. / Habash, J. / Helliwell, J.R. / Stoeckler, J.D. / Parksjunior, R.E. / Chen, S.-F. / Bugg, C.E. #2: ![]() Title: Crystallization and Preliminary X-Ray Investigation of Human Erythrocyte Purine Nucleoside Phosphorylase Authors: Cook, W.J. / Ealick, S.E. / Bugg, C.E. / Stoeckler, J.D. / Parksjunior, R.E. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 67.7 KB | Display | ![]() |
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PDB format | ![]() | 51 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 32184.877 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() References: UniProt: P00491, ![]() |
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#2: Chemical | ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 5.04 Å3/Da / Density % sol: 75.61 % |
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Crystal grow![]() | *PLUS Method: unknown |
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Processing
Software | Name: PROLSQ / Classification: refinement | ||||||||||||
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Refinement | Rfactor obs: 0.202 / Highest resolution: 2.75 Å | ||||||||||||
Refinement step | Cycle: LAST / Highest resolution: 2.75 Å
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