登録情報 | データベース: PDB / ID: 1u7v |
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タイトル | Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex |
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要素 | - Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 4
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キーワード | SIGNALING PROTEIN / Smad / TGF-beta / signal transduction / protein complex / phosphorylation |
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機能・相同性 | 機能・相同性情報
positive regulation of cell proliferation involved in heart valve morphogenesis / female gonad morphogenesis / negative regulation of cardiac myofibril assembly / zygotic specification of dorsal/ventral axis / regulation of binding / metanephric mesenchyme morphogenesis / nephrogenic mesenchyme morphogenesis / somite rostral/caudal axis specification / atrioventricular valve formation / homomeric SMAD protein complex ...positive regulation of cell proliferation involved in heart valve morphogenesis / female gonad morphogenesis / negative regulation of cardiac myofibril assembly / zygotic specification of dorsal/ventral axis / regulation of binding / metanephric mesenchyme morphogenesis / nephrogenic mesenchyme morphogenesis / somite rostral/caudal axis specification / atrioventricular valve formation / homomeric SMAD protein complex / paraxial mesoderm morphogenesis / mesendoderm development / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / positive regulation of luteinizing hormone secretion / regulation of hair follicle development / filamin binding / sebaceous gland development / SMAD protein complex / formation of anatomical boundary / epithelial cell migration / RUNX2 regulates bone development / endoderm formation / positive regulation of follicle-stimulating hormone secretion / co-SMAD binding / heteromeric SMAD protein complex / regulation of transforming growth factor beta2 production / neuron fate specification / determination of left/right asymmetry in lateral mesoderm / odontoblast differentiation / RUNX3 regulates BCL2L11 (BIM) transcription / endocardial cell differentiation / epithelial to mesenchymal transition involved in endocardial cushion formation / response to transforming growth factor beta / secondary palate development / pericardium development / FOXO-mediated transcription of cell cycle genes / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / negative regulation of cardiac muscle hypertrophy / brainstem development / left ventricular cardiac muscle tissue morphogenesis / Transcriptional regulation of pluripotent stem cells / regulation of transforming growth factor beta receptor signaling pathway / embryonic foregut morphogenesis / atrioventricular canal development / cardiac conduction system development / positive regulation of extracellular matrix assembly / primary miRNA processing / transforming growth factor beta receptor binding / Germ layer formation at gastrulation / sulfate binding / pulmonary valve morphogenesis / Signaling by BMP / Formation of definitive endoderm / type I transforming growth factor beta receptor binding / cellular response to BMP stimulus / outflow tract septum morphogenesis / signal transduction involved in regulation of gene expression / activin receptor signaling pathway / Signaling by Activin / SMAD protein signal transduction / Formation of axial mesoderm / positive regulation of BMP signaling pathway / Signaling by NODAL / cardiac muscle hypertrophy in response to stress / embryonic cranial skeleton morphogenesis / response to cholesterol / gastrulation with mouth forming second / I-SMAD binding / aortic valve morphogenesis / pancreas development / neural crest cell differentiation / endothelial cell activation / Cardiogenesis / insulin secretion / RUNX3 regulates CDKN1A transcription / anterior/posterior pattern specification / ureteric bud development / endocardial cushion morphogenesis / organ growth / embryonic digit morphogenesis / branching involved in ureteric bud morphogenesis / adrenal gland development / ventricular septum morphogenesis / interleukin-6-mediated signaling pathway / seminiferous tubule development / positive regulation of cardiac muscle cell apoptotic process / positive regulation of transforming growth factor beta receptor signaling pathway / SMAD binding / TGF-beta receptor signaling activates SMADs / R-SMAD binding / uterus development / positive regulation of SMAD protein signal transduction / mesoderm formation / developmental growth / single fertilization / epithelial to mesenchymal transition類似検索 - 分子機能 Tumour Suppressor Smad4 - #10 / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type ...Tumour Suppressor Smad4 - #10 / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / Tumour Suppressor Smad4 / SMAD/FHA domain superfamily / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Mothers against decapentaplegic homolog 4 / Mothers against decapentaplegic homolog 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Chacko, B.M. / Qin, B.Y. / Tiwari, A. / Shi, G. / Lam, S. / Hayward, L.J. / de Caestecker, M. / Lin, K. |
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引用 | ジャーナル: Mol.Cell / 年: 2004 タイトル: Structural basis of heteromeric smad protein assembly in tgf-Beta signaling 著者: Chacko, B.M. / Qin, B.Y. / Tiwari, A. / Shi, G. / Lam, S. / Hayward, L.J. / De Caestecker, M. / Lin, K. |
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履歴 | 登録 | 2004年8月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2004年9月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2023年8月23日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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