Entry Database : PDB / ID : 1u7f Structure visualization Downloads & linksTitle Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex ComponentsMothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 DetailsKeywords SIGNALING PROTEIN / Smad / TGF-beta / signal transduction / protein complex / phosphorylationFunction / homology Function and homology informationFunction Domain/homology Component
nuclear mineralocorticoid receptor binding / negative regulation of lung blood pressure / regulation of miRNA transcription / positive regulation of cell proliferation involved in heart valve morphogenesis / female gonad morphogenesis / negative regulation of cardiac myofibril assembly / positive regulation of transforming growth factor beta3 production / metanephric mesenchyme morphogenesis / nephrogenic mesenchyme morphogenesis / somite rostral/caudal axis specification ... nuclear mineralocorticoid receptor binding / negative regulation of lung blood pressure / regulation of miRNA transcription / positive regulation of cell proliferation involved in heart valve morphogenesis / female gonad morphogenesis / negative regulation of cardiac myofibril assembly / positive regulation of transforming growth factor beta3 production / metanephric mesenchyme morphogenesis / nephrogenic mesenchyme morphogenesis / somite rostral/caudal axis specification / atrioventricular valve formation / transdifferentiation / sterol response element binding / paraxial mesoderm morphogenesis / mesendoderm development / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / positive regulation of luteinizing hormone secretion / regulation of hair follicle development / regulation of striated muscle tissue development / filamin binding / sebaceous gland development / SMAD protein complex / formation of anatomical boundary / immune system development / epithelial cell migration / RUNX2 regulates bone development / positive regulation of follicle-stimulating hormone secretion / co-SMAD binding / heteromeric SMAD protein complex / regulation of transforming growth factor beta2 production / neuron fate specification / RUNX3 regulates BCL2L11 (BIM) transcription / endocardial cell differentiation / epithelial to mesenchymal transition involved in endocardial cushion formation / DEAD/H-box RNA helicase binding / response to transforming growth factor beta / secondary palate development / bHLH transcription factor binding / pericardium development / FOXO-mediated transcription of cell cycle genes / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / positive regulation of chondrocyte differentiation / negative regulation of osteoblast proliferation / negative regulation of cardiac muscle hypertrophy / brainstem development / left ventricular cardiac muscle tissue morphogenesis / Transcriptional regulation of pluripotent stem cells / regulation of transforming growth factor beta receptor signaling pathway / embryonic foregut morphogenesis / atrioventricular canal development / negative regulation of wound healing / cardiac conduction system development / positive regulation of extracellular matrix assembly / lens fiber cell differentiation / primary miRNA processing / transforming growth factor beta receptor binding / Germ layer formation at gastrulation / sulfate binding / Signaling by BMP / nuclear glucocorticoid receptor binding / endoderm development / cellular response to BMP stimulus / Formation of definitive endoderm / embryonic pattern specification / outflow tract septum morphogenesis / signal transduction involved in regulation of gene expression / activin receptor signaling pathway / Signaling by Activin / SMAD protein signal transduction / Formation of axial mesoderm / cell-cell junction organization / Signaling by NODAL / regulation of epithelial cell proliferation / cardiac muscle hypertrophy in response to stress / embryonic cranial skeleton morphogenesis / gastrulation with mouth forming second / I-SMAD binding / Interleukin-37 signaling / response to angiotensin / neural crest cell differentiation / endothelial cell activation / Cardiogenesis / positive regulation of positive chemotaxis / osteoblast development / NOTCH4 Intracellular Domain Regulates Transcription / negative regulation of cardiac muscle hypertrophy in response to stress / RUNX3 regulates CDKN1A transcription / nuclear inner membrane / ureteric bud development / DNA-binding transcription repressor activity / embryonic digit morphogenesis / branching involved in ureteric bud morphogenesis / adrenal gland development / ventricular septum morphogenesis / interleukin-6-mediated signaling pathway / negative regulation of fat cell differentiation Similarity search - Function Tumour Suppressor Smad4 - #10 / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type ... Tumour Suppressor Smad4 - #10 / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / Tumour Suppressor Smad4 / SMAD/FHA domain superfamily / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.6 Å DetailsAuthors Chacko, B.M. / Qin, B.Y. / Tiwari, A. / Shi, G. / Lam, S. / Hayward, L.J. / de Caestecker, M. / Lin, K. CitationJournal : Mol.Cell / Year : 2004Title : Structural basis of heteromeric smad protein assembly in tgf-Beta signalingAuthors : Chacko, B.M. / Qin, B.Y. / Tiwari, A. / Shi, G. / Lam, S. / Hayward, L.J. / De Caestecker, M. / Lin, K. History Deposition Aug 3, 2004 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 28, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Aug 23, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details
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