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- PDB-1tum: MUTT PYROPHOSPHOHYDROLASE-METAL-NUCLEOTIDE-METAL COMPLEX, NMR, 16... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1tum | ||||||
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Title | MUTT PYROPHOSPHOHYDROLASE-METAL-NUCLEOTIDE-METAL COMPLEX, NMR, 16 STRUCTURES | ||||||
![]() | MUTATOR MUTT PROTEIN | ||||||
![]() | MUTATOR PROTEIN / QUATERNARY COMPLEX / NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE / MUTT PYROPHOSPHOHYDROLASE-METAL-SUBSTRATE ANALOG COMPLEX | ||||||
Function / homology | ![]() dGDP catabolic process / 8-oxo-dGTP diphosphatase / 8-oxo-GDP phosphatase activity / 8-oxo-dGDP phosphatase activity / dGTP catabolic process / 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / nucleotide-excision repair / manganese ion binding / DNA replication ...dGDP catabolic process / 8-oxo-dGTP diphosphatase / 8-oxo-GDP phosphatase activity / 8-oxo-dGDP phosphatase activity / dGTP catabolic process / 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / nucleotide-excision repair / manganese ion binding / DNA replication / DNA repair / magnesium ion binding Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Lin, J. / Abeygunawardana, C. / Frick, D.N. / Bessman, M.J. / Mildvan, A.S. | ||||||
![]() | ![]() Title: Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action. Authors: Lin, J. / Abeygunawardana, C. / Frick, D.N. / Bessman, M.J. / Mildvan, A.S. #1: ![]() Title: NMR Studies of the Conformations and Location of Nucleotides Bound to the E.Coli Mutt Enzyme Authors: Frick, D.N. / Weber, D.J. / Abeygunawardana, C. / Gittis, A.G. / Bessman, M.J. / Mildvan, A.S. #2: ![]() Title: Solution Structure of the Mutt Enzyme, a Nucleoside Triphosphate Pyrophosphohydrolase Authors: Abeygunawardana, C. / Weber, D.J. / Gittis, A.G. / Frick, D.N. / Lin, J. / Miller, A.F. / Bessman, M.J. / Mildvan, A.S. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 683.5 KB | Display | ![]() |
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PDB format | ![]() | 563.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 459.1 KB | Display | ![]() |
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Full document | ![]() | 699.8 KB | Display | |
Data in XML | ![]() | 106.5 KB | Display | |
Data in CIF | ![]() | 134.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 |
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NMR ensembles |
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Components
#1: Protein | Mass: 14945.029 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: MUTT-MG(2+)-AMPCPP-MG(2+) COMPLEX / Source: (gene. exp.) ![]() ![]() ![]() ![]() References: UniProt: P08337, Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides |
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#2: Chemical | ChemComp-MG / |
#3: Chemical | ChemComp-APC / |
#4: Chemical | ChemComp-CON / |
#5: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Sample conditions | pH: 7.6 / Temperature: 305 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
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NMR software | Name: ![]() | ||||||||||||
NMR ensemble | Conformers submitted total number: 16 |