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Yorodumi- PDB-1tle: LE (LAMININ-TYPE EGF-LIKE) MODULE GIII4 IN SOLUTION AT PH 3.5 AND... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1tle | ||||||
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Title | LE (LAMININ-TYPE EGF-LIKE) MODULE GIII4 IN SOLUTION AT PH 3.5 AND 290 K, NMR, 14 STRUCTURES | ||||||
Components | LAMININ | ||||||
Keywords | GLYCOPROTEIN / EXTRACELLULAR MATRIX PROTEIN / NIDOGEN BINDING / LE-MODULE | ||||||
Function / homology | Function and homology information laminin-1 complex / laminin-10 complex / tissue morphogenesis / hair follicle cell proliferation / regulation of basement membrane organization / hemidesmosome assembly / positive regulation of integrin-mediated signaling pathway / glycosphingolipid binding / tissue development / hair cell differentiation ...laminin-1 complex / laminin-10 complex / tissue morphogenesis / hair follicle cell proliferation / regulation of basement membrane organization / hemidesmosome assembly / positive regulation of integrin-mediated signaling pathway / glycosphingolipid binding / tissue development / hair cell differentiation / protein complex involved in cell-matrix adhesion / extracellular matrix structural constituent / hair follicle morphogenesis / positive regulation of muscle cell differentiation / basement membrane / positive regulation of cell adhesion / extracellular matrix disassembly / synaptic cleft / substrate adhesion-dependent cell spreading / animal organ morphogenesis / neuromuscular junction / neuron projection development / cell migration / gene expression / chromatin organization / protein-containing complex assembly / collagen-containing extracellular matrix / cell adhesion / extracellular region Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Baumgartner, R. / Czisch, M. / Mayer, U. / Schl, E.P. / Huber, R. / Timpl, R. / Holak, T.A. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 1996 Title: Structure of the nidogen binding LE module of the laminin gamma1 chain in solution. Authors: Baumgartner, R. / Czisch, M. / Mayer, U. / Poschl, E. / Huber, R. / Timpl, R. / Holak, T.A. #1: Journal: Embo J. / Year: 1994 Title: Two Non-Contiguous Regions Contribute to Nidogen Binding to a Single Egf-Like Motif of the Laminin Gamma 1 Chain Authors: Poschl, E. / Fox, J.W. / Block, D. / Mayer, U. / Timpl, R. #2: Journal: Embo J. / Year: 1993 Title: A Single Egf-Like Motif of Laminin is Responsible for High Affinity Nidogen Binding Authors: Mayer, U. / Nischt, R. / Poschl, E. / Mann, K. / Fukuda, K. / Gerl, M. / Yamada, Y. / Timpl, R. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1tle.cif.gz | 237.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1tle.ent.gz | 205.7 KB | Display | PDB format |
PDBx/mmJSON format | 1tle.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tl/1tle ftp://data.pdbj.org/pub/pdb/validation_reports/tl/1tle | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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NMR ensembles |
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-Components
#1: Protein | Mass: 6352.206 Da / Num. of mol.: 1 Fragment: NIDOGEN BINDING LE MODULE OF THE LAMININ GAMMA1 CHAIN, MODULE GIII4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Tissue: BASEMENT MEMBRANE / Gene: LAMC1 / Plasmid: PCEP4 / Gene (production host): LAMC1 / Production host: Mus musculus (house mouse) / References: UniProt: P02468 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Sample conditions | pH: 3.5 / Temperature: 290 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformers submitted total number: 14 |