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- PDB-1tku: Crystal Structure of 3,4-Dihydroxy-2-butanone 4-phosphate Synthas... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1tku | ||||||
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Title | Crystal Structure of 3,4-Dihydroxy-2-butanone 4-phosphate Synthase of Candida albicans in complex with Ribulose-5-phosphate | ||||||
![]() | 3,4-Dihydroxy-2-butanone 4-phosphate Synthase | ||||||
![]() | ISOMERASE / Candida albicans / riboflavin biosynthesis / 3 / 4-dihydroxy-2-butanone 4-phosphate synthase / synthetic gene | ||||||
Function / homology | ![]() 3,4-dihydroxy-2-butanone-4-phosphate synthase / 3,4-dihydroxy-2-butanone-4-phosphate synthase activity / riboflavin biosynthetic process / metal ion binding / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Echt, S. / Bauer, S. / Steinbacher, S. / Huber, R. / Bacher, A. / Fischer, M. | ||||||
![]() | ![]() Title: Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans. Authors: Echt, S. / Bauer, S. / Steinbacher, S. / Huber, R. / Bacher, A. / Fischer, M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 103.8 KB | Display | ![]() |
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PDB format | ![]() | 77.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 454.6 KB | Display | ![]() |
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Full document | ![]() | 465.5 KB | Display | |
Data in XML | ![]() | 25.1 KB | Display | |
Data in CIF | ![]() | 38.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1tksC ![]() 1g57S S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 22684.982 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() References: GenBank: 46438026, UniProt: Q5A3V6*PLUS, Isomerases; Intramolecular transferases; Transferring other groups #2: Sugar | #3: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.16 Å3/Da / Density % sol: 43 % |
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Crystal grow | Temperature: 293 K / Method: vapor diffusion, sitting drop / pH: 6 Details: Mes/NaOH, PEG8000, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() |
Detector | Type: MARRESEARCH / Detector: IMAGE PLATE / Date: Jul 21, 2003 |
Radiation | Monochromator: GRAPHITE / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.542 Å / Relative weight: 1 |
Reflection | Resolution: 1.66→20 Å / Num. obs: 39461 / % possible obs: 77.3 % / Redundancy: 3.2 % / Rmerge(I) obs: 0.032 / Net I/σ(I): 22.2 |
Reflection shell | Resolution: 1.66→1.672 Å / Rmerge(I) obs: 0.174 / % possible all: 28.7 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: 1G57 Resolution: 1.66→20 Å
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Refinement step | Cycle: LAST / Resolution: 1.66→20 Å
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LS refinement shell | Resolution: 1.66→1.72 Å
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