+Open data
-Basic information
Entry | Database: PDB / ID: 1tiu | ||||||
---|---|---|---|---|---|---|---|
Title | TITIN, IG REPEAT 27, NMR, 24 STRUCTURES | ||||||
Components | TITIN, I27 | ||||||
Keywords | IMMUNOGLOBULIN-LIKE DOMAIN / MUSCLE PROTEIN | ||||||
Function / homology | Function and homology information sarcomerogenesis / structural molecule activity conferring elasticity / telethonin binding / skeletal muscle myosin thick filament assembly / cardiac myofibril assembly / muscle alpha-actinin binding / detection of muscle stretch / cardiac muscle tissue morphogenesis / cardiac muscle hypertrophy / mitotic chromosome condensation ...sarcomerogenesis / structural molecule activity conferring elasticity / telethonin binding / skeletal muscle myosin thick filament assembly / cardiac myofibril assembly / muscle alpha-actinin binding / detection of muscle stretch / cardiac muscle tissue morphogenesis / cardiac muscle hypertrophy / mitotic chromosome condensation / Striated Muscle Contraction / actinin binding / M band / I band / protein kinase regulator activity / cardiac muscle cell development / structural constituent of muscle / sarcomere organization / skeletal muscle thin filament assembly / striated muscle thin filament / condensed nuclear chromosome / striated muscle contraction / muscle contraction / cardiac muscle contraction / protein kinase A signaling / positive regulation of protein secretion / response to calcium ion / Z disc / actin filament binding / Platelet degranulation / protein tyrosine kinase activity / protease binding / calmodulin binding / non-specific serine/threonine protein kinase / protein serine kinase activity / protein serine/threonine kinase activity / calcium ion binding / positive regulation of gene expression / protein kinase binding / enzyme binding / protein homodimerization activity / extracellular exosome / extracellular region / ATP binding / identical protein binding / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Improta, S. / Politou, A.S. / Pastore, A. | ||||||
Citation | Journal: Structure / Year: 1996 Title: Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity. Authors: Improta, S. / Politou, A.S. / Pastore, A. #1: Journal: Structure / Year: 1995 Title: Tertiary Structure of an Immunoglobulin-Like Domain from the Giant Muscle Protein Titin: A New Member of the I Set Authors: Pfuhl, M. / Pastore, A. #2: Journal: Science / Year: 1995 Title: Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity Authors: Labeit, S. / Kolmerer, B. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1tiu.cif.gz | 655.4 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1tiu.ent.gz | 534 KB | Display | PDB format |
PDBx/mmJSON format | 1tiu.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1tiu_validation.pdf.gz | 339.5 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 1tiu_full_validation.pdf.gz | 530.3 KB | Display | |
Data in XML | 1tiu_validation.xml.gz | 41.2 KB | Display | |
Data in CIF | 1tiu_validation.cif.gz | 64.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ti/1tiu ftp://data.pdbj.org/pub/pdb/validation_reports/ti/1tiu | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR ensembles |
|
-Components
#1: Protein | Mass: 10928.426 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: SOLUTION STRUCTURE, T=308K, PH 4.5, 10MM ACETATE BUFFER Source: (gene. exp.) Homo sapiens (human) / Tissue: MUSCLE / Cell line: 293 / Gene: TITIN GENE / Organ: HEART / Organelle: SARCOMERE / Plasmid: PET8C / Species (production host): Escherichia coli / Gene (production host): TITIN GENE / Production host: Escherichia coli BL21 (bacteria) / Strain (production host): BL21 / References: UniProt: Q10466, UniProt: Q8WZ42*PLUS |
---|
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
---|
-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
---|
-Processing
Software |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
NMR software | Name: X-PLOR (EXTENDED VERSION) / Version: VERSION) / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 24 |