登録情報 | データベース: PDB / ID: 1t76 |
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タイトル | Crystal structure of the androgen receptor ligand binding domain in complex with a WxxVW motif |
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要素 | - Androgen receptor
- WxxVW motif peptide
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キーワード | HORMONE/GROWTH FACTOR RECEPTOR / nuclear receptor / transcription factor / ligand binding domain / AF-2 / androgen / testosterone / DHT / alpha-helical sandwich / HORMONE-GROWTH FACTOR RECEPTOR COMPLEX |
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機能・相同性 | 機能・相同性情報
negative regulation of integrin biosynthetic process / androgen binding / intracellular receptor signaling pathway / androgen receptor signaling pathway / regulation of protein localization to plasma membrane / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / positive regulation of phosphorylation / steroid binding / negative regulation of extrinsic apoptotic signaling pathway ...negative regulation of integrin biosynthetic process / androgen binding / intracellular receptor signaling pathway / androgen receptor signaling pathway / regulation of protein localization to plasma membrane / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / positive regulation of phosphorylation / steroid binding / negative regulation of extrinsic apoptotic signaling pathway / beta-catenin binding / nuclear receptor activity / male gonad development / positive regulation of NF-kappaB transcription factor activity / transcription cis-regulatory region binding / DNA-binding transcription factor activity / positive regulation of cell population proliferation / positive regulation of gene expression / chromatin / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 Androgen receptor / Androgen receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors ...Androgen receptor / Androgen receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 5-ALPHA-DIHYDROTESTOSTERONE / Androgen receptor類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Pan troglodytes (チンパンジー) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Hur, E. / Pfaff, S.J. / Payne, E.S. / Gron, H. / Buehrer, B.M. / Fletterick, R.J. |
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引用 | ジャーナル: Plos Biol. / 年: 2004 タイトル: Recognition and accommodation at the androgen receptor coactivator binding interface. 著者: Hur, E. / Pfaff, S.J. / Payne, E.S. / Gron, H. / Buehrer, B.M. / Fletterick, R.J. |
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履歴 | 登録 | 2004年5月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2004年8月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2024年2月14日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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