- PDB-1sdz: Crystal structure of DIAP1 BIR1 bound to a Reaper peptide -
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Basic information
Entry
Database: PDB / ID: 1sdz
Title
Crystal structure of DIAP1 BIR1 bound to a Reaper peptide
Components
Apoptosis 1 inhibitor
Reaper
Keywords
APOPTOSIS / IAP / Reaper / caspase / interaction
Function / homology
Function and homology information
SMAC, XIAP-regulated apoptotic response / DS ligand bound to FT receptor / negative regulation of compound eye retinal cell programmed cell death / antennal morphogenesis / Deactivation of the beta-catenin transactivating complex / Regulation of necroptotic cell death / Regulation of PTEN localization / Activation of caspases through apoptosome-mediated cleavage / Regulation of the apoptosome activity / sensory organ precursor cell division ...SMAC, XIAP-regulated apoptotic response / DS ligand bound to FT receptor / negative regulation of compound eye retinal cell programmed cell death / antennal morphogenesis / Deactivation of the beta-catenin transactivating complex / Regulation of necroptotic cell death / Regulation of PTEN localization / Activation of caspases through apoptosome-mediated cleavage / Regulation of the apoptosome activity / sensory organ precursor cell division / Regulation of PTEN stability and activity / spermatid nucleus differentiation / positive regulation of Toll signaling pathway / border follicle cell migration / positive regulation of border follicle cell migration / chaeta development / caspase binding / negative regulation of JNK cascade / protein neddylation / ubiquitin conjugating enzyme binding / ubiquitin-like protein conjugating enzyme binding / NEDD8 ligase activity / cysteine-type endopeptidase inhibitor activity / ubiquitin-specific protease binding / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / protein autoubiquitination / protein K48-linked ubiquitination / positive regulation of protein ubiquitination / RING-type E3 ubiquitin transferase / Wnt signaling pathway / protein polyubiquitination / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / positive regulation of canonical Wnt signaling pathway / spermatogenesis / regulation of cell cycle / apoptotic process / ubiquitin protein ligase binding / negative regulation of apoptotic process / perinuclear region of cytoplasm / zinc ion binding / nucleus / cytoplasm / cytosol Similarity search - Function
Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. / Baculoviral inhibition of apoptosis protein repeat / Zinc finger, C3HC4 type (RING finger) / Ring finger / Zinc finger RING-type profile. ...Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. / Baculoviral inhibition of apoptosis protein repeat / Zinc finger, C3HC4 type (RING finger) / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Apoptosis1inhibitor / Inhibitor of apoptosis 1 / dIAP1 / Thread protein
Mass: 13552.203 Da / Num. of mol.: 1 / Fragment: DIAP1 BIR1 domain Source method: isolated from a genetically manipulated source Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Gene: IAP1, TH / Production host: Escherichia coli (E. coli) / References: UniProt: Q24306
#2: Protein/peptide
Reaper
Mass: 1094.216 Da / Num. of mol.: 1 / Fragment: Reaper N-terminal peptide / Source method: obtained synthetically Details: The sequence of this peptide occurs naturally in Drosophila (fruit flies).
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