- PDB-1s4y: Crystal structure of the activin/actrIIb extracellular domain -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 1s4y
Title
Crystal structure of the activin/actrIIb extracellular domain
Components
Activin receptor type IIB precursor
Inhibin beta A chain
Keywords
TRANSFERASE / structural genomics / JCSG / PSI / Protein Structure Initiative / Joint Center for Structural Genomics
Function / homology
Function and homology information
Signaling by Activin / activin A complex / inhibin A complex / cardiac fibroblast cell development / negative regulation of B cell differentiation / regulation of follicle-stimulating hormone secretion / inhibin binding / positive regulation of ovulation / GABAergic neuron differentiation / Signaling by BMP ...Signaling by Activin / activin A complex / inhibin A complex / cardiac fibroblast cell development / negative regulation of B cell differentiation / regulation of follicle-stimulating hormone secretion / inhibin binding / positive regulation of ovulation / GABAergic neuron differentiation / Signaling by BMP / activin receptor activity, type II / Antagonism of Activin by Follistatin / negative regulation of follicle-stimulating hormone secretion / progesterone secretion / lymphatic endothelial cell differentiation / type II activin receptor binding / striatal medium spiny neuron differentiation / positive regulation of activin receptor signaling pathway / activin receptor activity / Glycoprotein hormones / negative regulation of macrophage differentiation / venous blood vessel development / positive regulation of follicle-stimulating hormone secretion / cellular response to oxygen-glucose deprivation / hemoglobin biosynthetic process / lymphangiogenesis / retina vasculature development in camera-type eye / embryonic foregut morphogenesis / activin receptor complex / cellular response to follicle-stimulating hormone stimulus / cellular response to cholesterol / artery development / receptor protein serine/threonine kinase / pattern specification process / Signaling by BMP / activin binding / activin receptor signaling pathway / negative regulation of phosphorylation / SMAD protein signal transduction / Signaling by Activin / mesodermal cell differentiation / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / kinase activator activity / gastrulation with mouth forming second / cellular response to angiotensin / pancreas development / determination of left/right symmetry / skeletal system morphogenesis / negative regulation of cold-induced thermogenesis / insulin secretion / odontogenesis / positive regulation of transcription by RNA polymerase III / anterior/posterior pattern specification / organ growth / negative regulation of G1/S transition of mitotic cell cycle / response to aldosterone / roof of mouth development / eyelid development in camera-type eye / endodermal cell differentiation / growth factor binding / odontogenesis of dentin-containing tooth / mesoderm development / peptide hormone binding / positive regulation of SMAD protein signal transduction / negative regulation of type II interferon production / hair follicle development / positive regulation of collagen biosynthetic process / regulation of signal transduction / blood vessel remodeling / BMP signaling pathway / positive regulation of bone mineralization / hematopoietic progenitor cell differentiation / positive regulation of osteoblast differentiation / response to glucose / extrinsic apoptotic signaling pathway / ovarian follicle development / positive regulation of protein metabolic process / protein serine/threonine/tyrosine kinase activity / erythrocyte differentiation / post-embryonic development / positive regulation of erythrocyte differentiation / kidney development / skeletal system development / cytokine activity / growth factor activity / lung development / hormone activity / negative regulation of cell growth / cellular response to growth factor stimulus / defense response / autophagy / cytokine-mediated signaling pathway / male gonad development / cell-cell signaling / nervous system development / heart development / cellular response to hypoxia / transcription by RNA polymerase II / positive regulation of ERK1 and ERK2 cascade / cell surface receptor signaling pathway Similarity search - Function
Inhibin, beta A subunit / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal ...Inhibin, beta A subunit / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Cystine-knot cytokine / Ribbon / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta Similarity search - Domain/homology
In the structure databanks used in Yorodumi, some data are registered as the other names, "COVID-19 virus" and "2019-nCoV". Here are the details of the virus and the list of structure data.
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)
EMDB accession codes are about to change! (news from PDBe EMDB page)
The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
The EM Navigator/Yorodumi systems omit the EMD- prefix.
Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator
Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.
Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi