Entry Database : PDB / ID : 4uwx Structure visualization Downloads & linksTitle Structure of liprin-alpha3 in complex with mDia1 Diaphanous- inhibitory domain ComponentsLIPRIN-ALPHA-3 PROTEIN DIAPHANOUS HOMOLOG 1 DetailsKeywords PEPTIDE BINDING PROTEIN / PEPTIDE-BINDING PROTEIN / ACTIN POLYMERISATION / RHOGNBPS / SYNAPE MATURATION / CELL MOTILITY / FH1 / FH2 DOMAIN / ACTIN-NUCLEATION FACTOR - DIAPHANOUS-RELATED FORMINFunction / homology Function and homology informationFunction Domain/homology Component
epididymosome / Serotonin Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / Dopamine Neurotransmitter Release Cycle / Glutamate Neurotransmitter Release Cycle / negative regulation of neuron projection regeneration / multicellular organismal locomotion / RHOF GTPase cycle / Receptor-type tyrosine-protein phosphatases ... epididymosome / Serotonin Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / Dopamine Neurotransmitter Release Cycle / Glutamate Neurotransmitter Release Cycle / negative regulation of neuron projection regeneration / multicellular organismal locomotion / RHOF GTPase cycle / Receptor-type tyrosine-protein phosphatases / RHOB GTPase cycle / ERBB2 Regulates Cell Motility / RHOC GTPase cycle / RHOD GTPase cycle / RHOA GTPase cycle / actin nucleation / neuron projection retraction / synaptic vesicle docking / RHO GTPases Activate Formins / profilin binding / presynaptic active zone cytoplasmic component / neurotransmitter secretion / regulation of microtubule-based process / regulation of short-term neuronal synaptic plasticity / axon midline choice point recognition / presynaptic active zone / synaptic vesicle exocytosis / brush border / synaptic vesicle endocytosis / ephrin receptor signaling pathway / cytoskeleton organization / actin filament polymerization / Neutrophil degranulation / acrosomal vesicle / actin filament / sensory perception of sound / synapse organization / protein localization / brain development / small GTPase binding / ruffle membrane / spindle / neuron projection development / presynapse / actin binding / gene expression / regulation of cell shape / actin cytoskeleton organization / transmembrane transporter binding / positive regulation of cell migration / neuron projection / centrosome / glutamatergic synapse / synapse / identical protein binding / nucleus / cytoplasm Similarity search - Function Liprin-alpha, SAM domain repeat 1 / Liprin-alpha, SAM domain repeat 2 / Liprin-alpha, SAM domain repeat 3 / LAR-interacting protein, Liprin / Formin Homology Region 1 / Diaphanous, GTPase-binding domain superfamily / Diaphanous autoregulatory (DAD) domain / Diaphanous autoregulatory domain (DAD) profile. / Formin, FH3 domain / Formin, GTPase-binding domain ... Liprin-alpha, SAM domain repeat 1 / Liprin-alpha, SAM domain repeat 2 / Liprin-alpha, SAM domain repeat 3 / LAR-interacting protein, Liprin / Formin Homology Region 1 / Diaphanous, GTPase-binding domain superfamily / Diaphanous autoregulatory (DAD) domain / Diaphanous autoregulatory domain (DAD) profile. / Formin, FH3 domain / Formin, GTPase-binding domain / Diaphanous FH3 Domain / Diaphanous GTPase-binding Domain / Diaphanous FH3 Domain / Diaphanous GTPase-binding Domain / Rho GTPase-binding/formin homology 3 (GBD/FH3) domain / Rho GTPase-binding/formin homology 3 (GBD/FH3) domain profile. / Formin, FH2 domain / Formin, FH2 domain superfamily / Formin Homology 2 Domain / Formin homology-2 (FH2) domain profile. / Formin Homology 2 Domain / SAM domain (Sterile alpha motif) / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Armadillo-like helical / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.65 Å DetailsAuthors Brenig, J. / de Boor, S. / Knyphausen, P. / Kuhlmann, N. / Wroblowski, S. / Baldus, L. / Scislowski, L. / Artz, O. / Trauschies, P. / Baumann, U. ...Brenig, J. / de Boor, S. / Knyphausen, P. / Kuhlmann, N. / Wroblowski, S. / Baldus, L. / Scislowski, L. / Artz, O. / Trauschies, P. / Baumann, U. / Neundorf, I. / Lammers, M. CitationJournal : J.Biol.Chem. / Year : 2015Title : Structural and Biochemical Basis for the Inhibitory Effect of Liprin-Alpha3 on Mouse Diaphanous 1 (Mdia1) Function.Authors : Brenig, J. / De Boor, S. / Knyphausen, P. / Kuhlmann, N. / Wroblowski, S. / Baldus, L. / Scislowski, L. / Artz, O. / Trauschies, P. / Baumann, U. / Neundorf, I. / Lammers, M. History Deposition Aug 15, 2014 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 6, 2015 Provider : repository / Type : Initial releaseRevision 1.1 May 13, 2015 Group : Database referencesRevision 1.2 Jun 17, 2015 Group : Database referencesRevision 1.3 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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