- PDB-1re0: Structure of ARF1-GDP bound to Sec7 domain complexed with Brefeldin A -
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Basic information
Entry
Database: PDB / ID: 1re0
Title
Structure of ARF1-GDP bound to Sec7 domain complexed with Brefeldin A
Components
ADP-ribosylation factor 1
ARF guanine-nucleotide exchange factor 1
Keywords
PROTEIN TRANSPORT / all-helical / alph-beta
Function / homology
Function and homology information
guanyl-nucleotide exchange factor activity => GO:0005085 / Synthesis of PIPs at the Golgi membrane / synaptic vesicle budding / lysosomal membrane organization / positive regulation of late endosome to lysosome transport / regulation of phospholipid metabolic process / Synthesis of PIPs at the plasma membrane / Golgi to transport vesicle transport / phospholipase D activator activity / Intra-Golgi traffic ...guanyl-nucleotide exchange factor activity => GO:0005085 / Synthesis of PIPs at the Golgi membrane / synaptic vesicle budding / lysosomal membrane organization / positive regulation of late endosome to lysosome transport / regulation of phospholipid metabolic process / Synthesis of PIPs at the plasma membrane / Golgi to transport vesicle transport / phospholipase D activator activity / Intra-Golgi traffic / COPI-dependent Golgi-to-ER retrograde traffic / COPI-mediated anterograde transport / cellular bud / Golgi cis cisterna / trans-Golgi Network Vesicle Budding / mitotic cleavage furrow ingression / trans-Golgi Network Vesicle Budding / positive regulation of ER to Golgi vesicle-mediated transport / Lysosome Vesicle Biogenesis / regulation of receptor internalization / very-low-density lipoprotein particle assembly / Glycosphingolipid transport / Golgi Associated Vesicle Biogenesis / regulation of Arp2/3 complex-mediated actin nucleation / Intra-Golgi traffic / MHC class II antigen presentation / postsynaptic actin cytoskeleton organization / Synthesis of PIPs at the Golgi membrane / positive regulation of calcium ion-dependent exocytosis / intra-Golgi vesicle-mediated transport / regulation of ARF protein signal transduction / Nef Mediated CD4 Down-regulation / retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum / dendritic spine organization / long-term synaptic depression / COPI-dependent Golgi-to-ER retrograde traffic / Lysosome Vesicle Biogenesis / positive regulation of sodium ion transmembrane transport / extrinsic component of membrane / Golgi Associated Vesicle Biogenesis / positive regulation of dendritic spine development / cell leading edge / positive regulation of endocytosis / Synthesis of PIPs at the plasma membrane / intracellular copper ion homeostasis / endomembrane system / endoplasmic reticulum to Golgi vesicle-mediated transport / COPI-mediated anterograde transport / vesicle-mediated transport / MHC class II antigen presentation / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / sarcomere / small monomeric GTPase / positive regulation of protein secretion / macroautophagy / actin filament organization / intracellular protein transport / cellular response to virus / GDP binding / late endosome / actin cytoskeleton organization / postsynaptic density / neuron projection / protein domain specific binding / Golgi membrane / focal adhesion / GTPase activity / glutamatergic synapse / GTP binding / perinuclear region of cytoplasm / Golgi apparatus / magnesium ion binding / endoplasmic reticulum / protein-containing complex / mitochondrion / RNA binding / extracellular exosome / plasma membrane / cytoplasm / cytosol Similarity search - Function
Mon2/Sec7/BIG1-like, HUS domain / Mon2/Sec7/BIG1-like, HUS domain / Arf Nucleotide-binding Site Opener; domain 2 / Arf Nucleotide-binding Site Opener,domain 2 / Annexin V; domain 1 - #20 / Sec7 domain / Sec7, C-terminal domain superfamily / Sec7 domain superfamily / Sec7 domain / SEC7 domain profile. ...Mon2/Sec7/BIG1-like, HUS domain / Mon2/Sec7/BIG1-like, HUS domain / Arf Nucleotide-binding Site Opener; domain 2 / Arf Nucleotide-binding Site Opener,domain 2 / Annexin V; domain 1 - #20 / Sec7 domain / Sec7, C-terminal domain superfamily / Sec7 domain superfamily / Sec7 domain / SEC7 domain profile. / Sec7 domain / ADP-ribosylation factor 1-5 / Annexin V; domain 1 / small GTPase Arf family profile. / Sar1p-like members of the Ras-family of small GTPases / Small GTPase superfamily, ARF/SAR type / ADP-ribosylation factor family / ARF-like small GTPases; ARF, ADP-ribosylation factor / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
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