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- PDB-1pso: The crystal structure of human pepsin and its complex with pepstatin -
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Open data
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Basic information
Entry | Database: PDB / ID: 1pso | ||||||
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Title | The crystal structure of human pepsin and its complex with pepstatin | ||||||
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![]() | HYDROLASE/HYDROLASE INHIBITOR / ACID PROTEINASE / HYDROLASE-HYDROLASE INHIBITOR complex | ||||||
Function / homology | ![]() multivesicular body lumen / pepsin A / Surfactant metabolism / digestion / aspartic-type endopeptidase activity / proteolysis / extracellular exosome Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() | ||||||
![]() | Fujinaga, M. / Chernaia, M.M. / Tarasova, N. / Mosimann, S.C. / James, M.N.G. | ||||||
![]() | ![]() Title: Crystal structure of human pepsin and its complex with pepstatin. Authors: Fujinaga, M. / Chernaia, M.M. / Tarasova, N.I. / Mosimann, S.C. / James, M.N. #1: ![]() Title: Molecular and Crystal Structures of Monoclinic Porcine Pepsin Refined at 1.8 Angstroms Resolution Authors: Sielecki, A.R. / Fedorov, A.A. / Boodhoo, A. / Andreeva, N.S. / James, M.N.G. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 74.8 KB | Display | ![]() |
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PDB format | ![]() | 53.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 424.3 KB | Display | ![]() |
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Full document | ![]() | 425.7 KB | Display | |
Data in XML | ![]() | 16.5 KB | Display | |
Data in CIF | ![]() | 24.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Unit cell |
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Atom site foot note | 1: CIS PROLINE - PRO E 23 |
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Components
#1: Protein | Mass: 34631.887 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() |
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#2: Protein/peptide | |
#3: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.24 Å3/Da / Density % sol: 59.7 % | ||||||||||||||||||||
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Crystal grow | *PLUS Method: vapor diffusion, hanging drop | ||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Source: ![]() |
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Detector | Type: SAN DIEGO MULTIWIRE DETECTION SYSTEM / Detector: AREA DETECTOR / Date: Jun 17, 1994 |
Radiation | Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Num. obs: 31184 / % possible obs: 97 % / Observed criterion σ(I): 0 |
Reflection | *PLUS Highest resolution: 1.97 Å / Num. measured all: 166144 / Rmerge(I) obs: 0.054 |
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Processing
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Refinement | Resolution: 2→30 Å / σ(F): 0 Details: RESIDUES WITH ZERO OCCUPANCIES AND NEGATIVE B-FACTORS ARE DISORDERED AND THEIR POSITIONS ARE NOT CONSIDERED TO HAVE BEEN DETERMINED.
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Displacement parameters | Biso mean: 23 Å2 | ||||||||||||
Refinement step | Cycle: LAST / Resolution: 2→30 Å
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Refine LS restraints |
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Refine LS restraints | *PLUS
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