登録情報 | データベース: PDB / ID: 1ozn |
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タイトル | 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination |
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要素 | Reticulon 4 receptor |
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キーワード | SIGNALING PROTEIN / Nogo Receptor / MAD / Myelination Inhibition / Omgp / MAG / nogo-66 / p75 / Signal Transduction / Neuronal Regeneration / Ligand Binding |
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機能・相同性 | 機能・相同性情報
neuronal signal transduction / ganglioside GM1 binding / chondroitin sulfate binding / neuregulin receptor activity / ganglioside GT1b binding / negative regulation of axon regeneration / negative regulation of axon extension / Axonal growth inhibition (RHOA activation) / corpus callosum development / positive regulation of Rho protein signal transduction ...neuronal signal transduction / ganglioside GM1 binding / chondroitin sulfate binding / neuregulin receptor activity / ganglioside GT1b binding / negative regulation of axon regeneration / negative regulation of axon extension / Axonal growth inhibition (RHOA activation) / corpus callosum development / positive regulation of Rho protein signal transduction / axonal growth cone / axonogenesis / positive regulation of GTPase activity / dendritic shaft / negative regulation of neuron projection development / presynapse / signaling receptor activity / heparin binding / perikaryon / cell surface receptor signaling pathway / neuron projection / membrane raft / external side of plasma membrane / neuronal cell body / glutamatergic synapse / protein-containing complex binding / cell surface / endoplasmic reticulum / extracellular exosome / plasma membrane類似検索 - 分子機能 Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat ...Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 多波長異常分散 / 解像度: 1.52 Å |
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データ登録者 | He, X. / Bazan, J.F. / Park, J.B. / McDermott, G. / He, Z. / Garcia, K.C. |
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引用 | ジャーナル: Neuron / 年: 2003 タイトル: Structure of the Nogo Receptor Ectodomain. A Recognition module implicated in Myelin Inhibition. 著者: He, X.L. / Bazan, J.F. / McDermott, G. / Park, J.B. / Wang, K. / Tessier-Lavigne, M. / He, Z. / Garcia, K.C. |
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履歴 | 登録 | 2003年4月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2003年5月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月29日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_validate_chiral / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_comp_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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