Entry Database : PDB / ID : 1nun Structure visualization Downloads & linksTitle Crystal Structure Analysis of the FGF10-FGFR2b Complex ComponentsFibroblast growth factor-10 fibroblast growth factor receptor 2 isoform 2 DetailsKeywords HORMONE/GROWTH FACTOR/MEMBRANE PROTEIN / BETA-TREFOIL FOLD / IMMUNOGLOBULIN-LIKE DOMAIN / HORMONE-GROWTH FACTOR-MEMBRANE PROTEIN COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
urothelial cell proliferation / positive regulation of urothelial cell proliferation / bronchiole morphogenesis / mesenchymal-epithelial cell signaling involved in lung development / lung proximal/distal axis specification / tear secretion / positive regulation of white fat cell proliferation / positive regulation of hair follicle cell proliferation / embryonic genitalia morphogenesis / secretion by lung epithelial cell involved in lung growth ... urothelial cell proliferation / positive regulation of urothelial cell proliferation / bronchiole morphogenesis / mesenchymal-epithelial cell signaling involved in lung development / lung proximal/distal axis specification / tear secretion / positive regulation of white fat cell proliferation / positive regulation of hair follicle cell proliferation / embryonic genitalia morphogenesis / secretion by lung epithelial cell involved in lung growth / type 2 fibroblast growth factor receptor binding / regulation of activin receptor signaling pathway / semicircular canal fusion / muscle cell fate commitment / salivary gland development / regulation of cell cycle => GO:0051726 / type II pneumocyte differentiation / Harderian gland development / radial glial cell differentiation / : / lung saccule development / prostatic bud formation / regulation of saliva secretion / : / Regulation of gene expression in early pancreatic precursor cells / FGFRL1 modulation of FGFR1 signaling / lung epithelium development / female genitalia morphogenesis / submandibular salivary gland formation / Signaling by FGFR2 amplification mutants / Signaling by FGFR2 fusions / fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell / fibroblast growth factor receptor signaling pathway involved in hemopoiesis / fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow / bud outgrowth involved in lung branching / fibroblast growth factor receptor signaling pathway involved in mammary gland specification / lateral sprouting from an epithelium / mammary gland bud formation / branch elongation involved in salivary gland morphogenesis / mesenchymal cell differentiation involved in lung development / lacrimal gland development / otic vesicle formation / prostate gland morphogenesis / metanephros morphogenesis / embryonic camera-type eye development / positive regulation of keratinocyte proliferation / regulation of smooth muscle cell differentiation / orbitofrontal cortex development / regulation of morphogenesis of a branching structure / positive regulation of lymphocyte proliferation / squamous basal epithelial stem cell differentiation involved in prostate gland acinus development / branching morphogenesis of a nerve / embryonic organ morphogenesis / endochondral bone growth / morphogenesis of embryonic epithelium / pituitary gland development / epidermis morphogenesis / bud elongation involved in lung branching / positive regulation of epithelial cell proliferation involved in lung morphogenesis / pyramidal neuron development / mesonephros development / membranous septum morphogenesis / reproductive structure development / male genitalia morphogenesis / limb bud formation / lung lobe morphogenesis / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / gland morphogenesis / fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development / ventricular zone neuroblast division / positive regulation of epithelial cell proliferation involved in wound healing / embryonic digestive tract morphogenesis / epithelial cell proliferation involved in salivary gland morphogenesis / mesenchymal cell differentiation / branching involved in prostate gland morphogenesis / mesenchymal cell proliferation involved in lung development / positive regulation of keratinocyte migration / smooth muscle cell differentiation / branching involved in labyrinthine layer morphogenesis / tissue regeneration / FGFR2b ligand binding and activation / fibroblast growth factor receptor binding / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / regulation of osteoblast proliferation / Phospholipase C-mediated cascade; FGFR2 / fibroblast growth factor receptor activity / induction of positive chemotaxis / FGFR1b ligand binding and activation / embryonic pattern specification / branching involved in salivary gland morphogenesis / outflow tract septum morphogenesis / organ induction / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / positive regulation of phospholipase activity / lung-associated mesenchyme development / metanephros development / mesodermal cell differentiation / regulation of smoothened signaling pathway Similarity search - Function Fibroblast growth factor 10 / HBGF/FGF family signature. / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Fibroblast growth factor receptor family / Cytokine IL1/FGF / Immunoglobulin domain / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) ... Fibroblast growth factor 10 / HBGF/FGF family signature. / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Fibroblast growth factor receptor family / Cytokine IL1/FGF / Immunoglobulin domain / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.9 Å DetailsAuthors Yeh, B.K. / Igarashi, M. / Eliseenkova, A.V. / Plotnikov, A.N. / Sher, I. / Ron, D. / Aaronson, S.A. / Mohammadi, M. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2003Title : Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.Authors : Yeh, B.K. / Igarashi, M. / Eliseenkova, A.V. / Plotnikov, A.N. / Sher, I. / Ron, D. / Aaronson, S.A. / Mohammadi, M. History Deposition Jan 31, 2003 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 11, 2003 Provider : repository / Type : Initial releaseRevision 1.1 Apr 29, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format compliance
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