登録情報 | データベース: PDB / ID: 1mx2 |
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タイトル | Structure of F71N mutant of p18INK4c |
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要素 | Cyclin-dependent kinase 6 inhibitor |
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キーワード | cell cycle inhibitor / Ankyrin repeats |
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機能・相同性 | 機能・相同性情報
negative regulation of phosphorylation / cyclin-dependent protein serine/threonine kinase inhibitor activity / regulation of cyclin-dependent protein serine/threonine kinase activity / oligodendrocyte differentiation / regulation of G1/S transition of mitotic cell cycle / negative regulation of stem cell proliferation / stem cell proliferation / Cyclin D associated events in G1 / Oncogene Induced Senescence / negative regulation of cell growth ...negative regulation of phosphorylation / cyclin-dependent protein serine/threonine kinase inhibitor activity / regulation of cyclin-dependent protein serine/threonine kinase activity / oligodendrocyte differentiation / regulation of G1/S transition of mitotic cell cycle / negative regulation of stem cell proliferation / stem cell proliferation / Cyclin D associated events in G1 / Oncogene Induced Senescence / negative regulation of cell growth / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / negative regulation of cell population proliferation / protein kinase binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 : / Ankyrin repeat-containing domain / Ankyrin repeats (many copies) / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ...: / Ankyrin repeat-containing domain / Ankyrin repeats (many copies) / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.25 Å |
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データ登録者 | Marmorstein, R. / Venkataramani, R.N. / MacLachlan, T.K. / Chai, X. / El-Deiery, W.S. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2002 タイトル: Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity 著者: Venkataramani, R.N. / MacLachlan, T.K. / Chai, X. / El-Deiry, W.S. / Marmorstein, R. |
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履歴 | 登録 | 2002年10月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2002年10月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月28日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2021年10月27日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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改定 1.4 | 2024年2月14日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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